disease

epilepsy

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about epilepsy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2744Connections

0Hypotheses

1Analyses

43Outgoing

50Incoming

Summary

epilepsy is a disease characterized by neurodegeneration research. Key relationships include: associated with, treats, implicated in. Connected to 15 entities in the SciDEX knowledge graph.

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Disease Info

Prevalence	~50 million people worldwide
Associated Genes	MTOR, TNF, SEZ6, HCN1, HCN4, HCN2, SMC1A, PVALB
Therapeutic Agents	everolimus, ketogenic diet, senolytics, quercetin, cannabidiol, lithium
KG Connections	270 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

flowchart TD
    EPILEPSY(["EPILEPSY"])
    Epilepsy["Epilepsy"]
    Als["Als"]
    Inflammation["Inflammation"]
    Neurodegeneration["Neurodegeneration"]
    ALZHEIMER_S_DISEASE(["ALZHEIMER'S DISEASE"])
    ALZHEIMER(["ALZHEIMER"])
    Mtor["Mtor"]
    MTOR(["MTOR"])
    Alzheimer["Alzheimer"]
    Parkinson["Parkinson"]
    Neuroinflammation["Neuroinflammation"]

    EPILEPSY -->|"associated with"| Epilepsy
    EPILEPSY -->|"therapeutic target"| Als
    EPILEPSY -->|"therapeutic target"| Epilepsy
    EPILEPSY -->|"activates"| Inflammation
    EPILEPSY -->|"activates"| Als
    EPILEPSY -->|"activates"| Neurodegeneration
    EPILEPSY -->|"associated with"| ALZHEIMER_S_DISEASE
    EPILEPSY -->|"associated with"| ALZHEIMER
    EPILEPSY -->|"therapeutic target"| Mtor
    EPILEPSY -->|"therapeutic target"| MTOR
    ALZHEIMER_S_DISEASE -->|"associated with"| EPILEPSY
    EPILEPSY -->|"associated with"| Alzheimer
    EPILEPSY -->|"causes"| Epilepsy
    EPILEPSY -->|"associated with"| Parkinson
    EPILEPSY -->|"activates"| Neuroinflammation

    style EPILEPSY fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1321)

Target	Relation	Type	Str
temporal lobe	affects	brain_region	0.90
neurons	affects	cell_type	0.90
hippocampus	affects	brain_region	0.90
cortex	affects	brain_region	0.90
astrocytes	affects	cell_type	0.90
microglia	affects	cell_type	0.90
oxidative stress response	involves	pathway	0.90
neural stem cells	affects	cell_type	0.90
glutamate signaling	involves	pathway	0.80
glutamate receptor	involves	receptor	0.80
PI3K-AKT-mTOR signaling	involves	pathway	0.80
pyroptosis	involves	pathway	0.80
spinal cord	affects	brain_region	0.70
GABA-A receptor	involves	receptor	0.70
AMPA receptor	involves	receptor	0.70
purinergic receptor	involves	receptor	0.70
NMDA receptor	involves	receptor	0.70
dentate gyrus	affects	brain_region	0.70
interneurons	affects	cell_type	0.70
oligodendrocytes	affects	cell_type	0.70
GABAergic neurons	affects	cell_type	0.70
autophagy pathway	involves	pathway	0.70
blood-brain barrier	affects	brain_region	0.70
JAK-STAT signaling	involves	pathway	0.70
basal ganglia	affects	brain_region	0.60
thalamus	affects	brain_region	0.60
cerebellum	affects	brain_region	0.60
white matter	affects	brain_region	0.60
brainstem	affects	brain_region	0.60
calcium signaling	involves	pathway	0.60
synaptic vesicle	disrupts	organelle	0.60
adenosine	disrupts	neurotransmitter	0.60
insulin signaling	involves	pathway	0.60
ferroptosis	involves	pathway	0.60
synaptic plasticity	involves	pathway	0.60
unfolded protein response	involves	pathway	0.60
TGF-beta signaling	involves	pathway	0.60
senescence	involves	pathway	0.60
lipid metabolism	involves	pathway	0.60
mitochondrial function	involves	pathway	0.60
epigenetic regulation	involves	pathway	0.60
necroptosis	involves	pathway	0.60
glymphatic clearance	involves	pathway	0.60

Incoming (1423)

Source	Relation	Type	Str
everolimus	treats	drug	0.90
mTOR pathway	causes	pathway	0.80
SMC1A	associated_with	gene	0.80
GANAXOLONE	treats	drug	0.80
Reelin Signaling Pathway	associated_with	pathway	0.80
MTOR	associated_with	protein	0.70
TNF	associated_with	protein	0.70
SEZ6	associated_with	protein	0.70
ketogenic diet	treats	drug	0.70
mitochondrial metabolism	associated_with	process	0.70
HCN1	associated_with	gene	0.70
cannabidiol	treats	compound	0.70
HCN	activates	gene	0.70
lithium	treats	drug	0.70
AMPK	associated_with	protein	0.70
metformin	treats	drug	0.70
IL-1β	associated_with	protein	0.70
IL-6	associated_with	protein	0.70
RNA	regulates	gene	0.70
SST	therapeutic_target	gene	0.60
PVALB	associated_with	protein	0.60
SYN1	implicated_in	gene	0.60
HCN1	protects_against	gene	0.60
HCN1	inhibits	gene	0.60
HCN1	interacts_with	gene	0.60
HCN1	activates	gene	0.60
HCN1	expressed_in	gene	0.60
HCN1	regulates	gene	0.60
HCN1	promotes	gene	0.60
HCN1	treats	gene	0.60
GABRA1	associated_with	gene	0.60
ALOX5	implicated_in	gene	0.60
GAP43	inhibits	gene	0.60
GAP43	interacts_with	gene	0.60
OCLN	associated_with	gene	0.60
GBM	regulates	gene	0.60
GBM	interacts_with	gene	0.60
senolytics	treats	compound	0.60
quercetin	treats	compound	0.60
CACNA1G	associated_with	gene	0.60
CYP46A1	inhibits	gene	0.60
APOE	expressed_in	gene	0.60
APOE	inhibits	gene	0.60
AQP4	activates	gene	0.60
AQP4	regulates	gene	0.60
AQP4	expressed_in	gene	0.60
AQP4	associated_with	gene	0.60
HCN4	associated_with	gene	0.60
HCN2	associated_with	gene	0.60
HCN1	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do P/Q channel deficits paradoxically increase thalamic excitability despite

synaptic biology | 2026-04-14 | 1 hypotheses Top: 0.526

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

epilepsy

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Device Therapies Comparison for CBS/PSP

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

GRIA3 Gene

Astrocyte Reactivity Mechanism

CNTN5 — Contactin 5

Autophagy Mechanisms

ncam2

gabaergic-dysfunction

CNTN4 — Contactin 4

blood-brain-barrier

nf1-protein

Niemann-Pick Disease Type C (NPC)

Traumatic Brain Injury and Neurodegeneration Pathway

Excitotoxicity in Neurodegeneration

Neuronal Ceroid Lipofuscinosis (NCL)

Neuroprotection Strategies in Neurodegeneration

MACF1 — Microtubule-actin crosslinking factor 1