disease

ISCHEMIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ISCHEMIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2679Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	FOXO3, JUN, TAU, LC3, MTOR, P62, SQSTM1, PARKIN
Therapeutic Agents	KAEMPFEROL
KG Connections	832 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ISCHEMIA["<b>ISCHEMIA</b>"]
    LAMP1(["LAMP1"])
    ISCHEMIA -->|"regulates"| LAMP1
    MYC(["MYC"])
    ISCHEMIA -->|"regulates"| MYC
    RAS(["RAS"])
    ISCHEMIA -->|"regulates"| RAS
    SQSTM1(["SQSTM1"])
    ISCHEMIA -->|"activates"| SQSTM1
    NEURON["NEURON"]
    ISCHEMIA -->|"activates"| NEURON
    NEURONS["NEURONS"]
    ISCHEMIA -->|"activates"| NEURONS
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"associated_with"| ISCHEMIA
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"associated_with"| ISCHEMIA
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"associated_with"| ISCHEMIA
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated_with"| ISCHEMIA
    style ISCHEMIA fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (881)

Target	Relation	Type	Str
MACROPHAGES	activates	cell_type	0.80
GPX4	activates	gene	0.72
CELL DEATH	inhibits	phenotype	0.70
NEURON	treats	cell_type	0.70
CGAS-STING PATHWAY	regulates	pathway	0.70
CGAS-STING PATHWAY	activates	pathway	0.70
CA1	activates	brain_region	0.70
NLRP3 INFLAMMASOME	inhibits	pathway	0.70
NEURODEGENERATION	processes	disease	0.65
MICROGLIA	accumulates_in	cell_type	0.65
STING	causes	gene	0.65
TUMOR	processes	disease	0.65
T CELL	inhibits	cell_type	0.65
T CELLS	inhibits	cell_type	0.65
TUMOR	accumulates_in	disease	0.65
MACROPHAGE	contributes_to	cell_type	0.65
MACROPHAGES	contributes_to	cell_type	0.65
PINK1	contributes_to	gene	0.65
MICROGLIA	implicated_in	cell_type	0.65
NADH	regulates	gene	0.65
RAPAMYCIN	regulates	drug	0.65
NRF2	regulates	gene	0.65
RAPAMYCIN	targets	drug	0.65
ROS	causes	gene	0.65
MICROGLIA	treats	cell_type	0.65
NEURODEGENERATION	causes	phenotype	0.65
GPX4	targets	gene	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
HIPPOCAMPUS	activates	brain_region	0.65
RETINOPATHY	activates	disease	0.65
OXIDATIVE STRESS	causes	phenotype	0.65
PYROPTOSIS	activates	phenotype	0.65
OXIDATIVE STRESS	exacerbates	phenotype	0.65
SIRT1	activates	gene	0.65
SYK	regulates	gene	0.65
VEGF	inhibits	gene	0.65
NOTCH1	inhibits	gene	0.65
SUPEROXIDE	activates	phenotype	0.65
SUPEROXIDE	regulates	phenotype	0.65
PYROPTOSIS	causes	phenotype	0.65
STROKE	degrades	disease	0.65
ABCA1	activates	gene	0.65
APOPTOSIS	degrades	phenotype	0.65
COGNITIVE DECLINE	causes	phenotype	0.65
NRF2 PATHWAY	activates	pathway	0.65
NRF2 PATHWAY	regulates	pathway	0.65
OXIDATIVE PHOSPHORYLATION	inhibits	pathway	0.65
PRION DISEASE	inhibits	disease	0.65
PRION DISEASE	causes	disease	0.65
LAMP1	regulates	gene	0.60

Incoming (1798)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
MICROGLIA	associated_with	cell_type	1.00
ASTROCYTES	associated_with	cell_type	1.00
MICROGLIA	activates	cell_type	0.90
TNF	associated_with	gene	0.90
NEURON	associated_with	cell_type	0.86
PINK1	associated_with	gene	0.82
PARKINSON'S DISEASE	associated_with	disease	0.82
NF-KB	associated_with	protein	0.82
SOD1	associated_with	gene	0.82
MTOR	associated_with	gene	0.74
NRF2	inhibits	gene	0.74
CASP3	associated_with	gene	0.74
MTOR	inhibits	gene	0.74
NRF2	associated_with	gene	0.74
NRF2	activates	gene	0.74
ERK	associated_with	gene	0.74
AQP4	produces	gene	0.70
HDAC3	treats	gene	0.70
RELA	modifies	gene	0.70
RELA	causes	gene	0.70
SIRT3	modifies	gene	0.70
PARKIN	associated_with	gene	0.66
CCL2	inhibits	gene	0.65
ACHE	contributes_to	gene	0.65
INFLAMMATION	exacerbates	phenotype	0.65
MACROPHAGE	exacerbates	cell_type	0.65
KAEMPFEROL	treats	drug	0.65
METFORMIN	protects_against	drug	0.65
STROKE	activates	disease	0.65
ASTROCYTES	exacerbates	cell_type	0.65
NLRP3 INFLAMMASOME	activates	pathway	0.65
NEUROGENESIS	regulates	phenotype	0.65
DEMYELINATION	regulates	phenotype	0.65
PYROPTOSIS	exacerbates	phenotype	0.65
MICROGLIAL ACTIVATION	regulates	phenotype	0.65
NOTCH1	regulates	gene	0.65
CLU	encodes	gene	0.65
APOE	encodes	gene	0.65
SULFORAPHANE	activates	drug	0.65
PHAGOCYTOSIS	targets	phenotype	0.65
STING	targets	gene	0.65
EMPAGLIFLOZIN	protects_against	drug	0.65
EMPAGLIFLOZIN	inhibits	drug	0.65
RELA	phosphorylates	gene	0.65
JUN	associated_with	gene	0.64
P62	associated_with	protein	0.64
AKT	activates	gene	0.64
ASTROCYTE	activates	cell_type	0.60
ENDOTHELIAL	treats	cell_type	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.548

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ISCHEMIA

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

neuroinflammation

GRIA3 Gene

Microglial Cells — Cell Type Hierarchy

Astrocyte Reactivity Mechanism

williams-syndrome

CLCN10 — Chloride Voltage-Gated Channel 10

Oligodendrocytes

amyloid-beta-metalloproteinases

Vascular Cognitive Impairment (VCI)

Vitamin D Signaling Pathway in Neurodegeneration

blood-brain-barrier

Spinal Cord Stimulation-Affected Neurons

Traumatic Brain Injury and Neurodegeneration Pathway

Excitotoxicity in Neurodegeneration

NACET (N-Acetylcysteine Ethyl Ester)

NPAS3 Gene