| Gene Symbol | SNCB |
| Full Name | Beta-Synuclein |
| Chromosome | 5q35.2 |
| Function | Beta-synuclein is expressed at high levels in the brain, particularly in presynaptic terminals where it performs several important functions: |
| Molecular Weight | 14 kDa |
| Amino Acids | 134 aa |
| UniProt ID | P37840 |
| NCBI Gene ID | 6622 |
| Ensembl ID | ENSG00000100030 |
| OMIM | 163890 |
| GeneCards | SNCB |
| Human Protein Atlas | SNCB |
| Inhibition of Fibril Formation | Beta-synuclein directly binds to alpha-synuclein, preventing its aggregation into toxic oligomers and fibrils |
| Heterooligomer Formation | The two proteins can form mixed oligomers that are less toxic than alpha-synuclein-only aggregates |
| Co-aggregation | When both proteins are present, they co-aggregate, diluting the overall toxicity of the inclusions |
| Associated Diseases | neurodegeneration |
| SciDEX Hypotheses | Ganglioside-rich extracellular vesicles preserve a |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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