gene 1,646 words KG: NDUFS6 2026-03-28
kind:genesection:genestopic:alzheimerstopic:parkinsonsstate:published
Contents

NDUFS6 Gene

🧬 Gene Info
Gene SymbolNDUFS6
Full NameNADH:Ubiquinone Oxidoreductase Core Subunit S6
Chromosome5p14.3
Protein FamilyComplex I subunit family (NADH dehydrogenase)
Functionis a critical iron-sulfur subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase), the largest enzyme of the mitochondrial electron transport chain.
Molecular Weight~13 kDa
Amino Acids124 aa
UniProt IDO75306
NCBI Gene ID4729
Ensembl IDENSG00000145494
OMIM602152
GeneCardsNDUFS6
Human Protein AtlasNDUFS6
Alternative NameTYKY
Length124 amino acids
Associated DiseasesAlzheimer's disease, Parkinson's disease
KG Connections43 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.41

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: regulates
SNCB Gene
gene · KG edge: co_mentioned
PDGFRB — Platelet Derived Growth Factor Receptor Beta
gene · KG edge: associated_with
NDUFS5 — NADH:Ubiquinone Oxidoreductase Core Subunit S5
gene · KG edge: associated_with
NDUFA2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NDUFS6 associated_with NDUFA1
NDUFS6 associated_with CBL
NDUFS6 associated_with PDGFRB
NDUFS6 associated_with HSP90AB1
NDUFS6 associated_with CRKL
NDUFS6 associated_with DOCK1
NDUFS6 associated_with NDUFA12
NDUFS6 associated_with YWHAH
NDUFS6 associated_with NDUFS5
NDUFS6 expressed_in MAPT