gene 1,998 words KG: HSPE1 2026-03-24
kind:genesection:genesstate:published
Contents

HSPE1 — Heat Shock Protein Family E Member 1

🧬 Gene Info
Gene SymbolHSPE1
Full NameHeat Shock Protein Family E Member 1
Chromosome2q33.1
Protein TypeChaperone
Functionis a mitochondrial co-chaperone protein that functions as a heptameric ring complex together with HSP60 (encoded by HSPD1).
Primary ExpressionUbiquitous, high in brain
Subcellular LocalizationMitochondria (matrix)
Molecular Weight10 kDa
UniProt IDP61604
NCBI Gene ID3336
OMIM600351
GeneCardsHSPE1
Human Protein AtlasHSPE1
AliasHSP10, Cpn10, GroES
Protein ClassChaperone, Co-chaperone
Associated DiseasesAlzheimer
InteractionsOPA1, LAMP2, BNIP3L, SIRT1, HTRA2, PARK2
KG Connections114 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

HSP60 (Heat Shock Protein 60)
protein · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: associated_with
HSP70 Inducer Therapies for Neurodegeneration
idea · KG edge: expressed_in
HSPA9 Gene
gene · KG edge: inhibits
HSPA6
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

HSPE1 inhibits OPA1
HSPE1 inhibits LAMP2
HSPE1 inhibits BNIP3L
HSPE1 inhibits SIRT1
HSPE1 inhibits HTRA2
HSPE1 inhibits PARK2
HSPE1 inhibits PINK1
HSPE1 inhibits TIMM17A
HSPE1 inhibits EIF2A
HSPE1 inhibits TFAM