| Gene Symbol | ent-gene-257405c9 |
| Disease | Source of Cytoplasmic DNA |
| Alzheimer's Disease | Mitochondrial DNA leakage, Tau-induced nuclear envelope rupture |
| Parkinson's Disease | Mitochondrial dysfunction, PINK1/Parkin mitophagy failure |
| ALS/FTD | TDP-43 mislocalization, C9orf72 repeat expansions |
| CBS/PSP | 4R Tau pathology, nuclear envelope stress |
| Huntington's Disease | Polyglutamine expansions, mitochondrial dysfunction |
| Compound | Developer |
| H-151 | Novartis |
| C-176 | Various |
| G150 | Research |
| AST-008 | AiCuris |
| BMS-986302 | Bristol Myers Squibb |
| RU.521 | Various |
| hydroxychloroquine | Repurposed |
| Combination | Rationale |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |