therapeutic 1,162 words KG: ent-gene-108079b2 2026-03-28
kind:therapeuticsection:therapeuticstopic:cxcl12topic:cxcr4topic:cxcr7topic:alzheimerstopic:parkinsonstopic:alstopic:cbstopic:psptopic:ftdtopic:hd
Contents

CXCL12/CXCR4 Axis Modulator Therapy for Neurodegeneration

🔬 Protein Info
Gene Symbolent-gene-108079b2
Cell TypeCXCR4 Expression
NeuronsHigh
AstrocytesModerate
MicrogliaLow (↑ in disease)
Neural Stem CellsHigh
Endothelial CellsModerate
CompoundMechanism
AMD3100 (Plerixafor)Small molecule antagonist
Ulocuplumab (BMS-936564)Anti-CXCR4 antibody
Balixafortide (POL6326)Cycl peptide antagonist
TN14003Peptide antagonist
CXCR7 Agonistsβ-arrestin biased signaling
CCX771CXCR7 selective antagonist
CCX266CXCR7 agonist
AgentTarget
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.82
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.79
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.77
Transcriptional Autophagy-Lysosome Coupling
Score: 0.77
CYP46A1 Overexpression Gene Therapy
Score: 0.75

Related Analyses (28)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses
WNK1 Kinase in Neurodegeneration
mechanism · Pages share 139 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 139 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 139 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 139 hypotheses