therapeutic 963 words KG: ent-gene-6e1f0bee 2026-03-22
kind:therapeuticsection:therapeuticsstate:published
Contents

GDNF Therapy for Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-6e1f0bee
Primary ExpressionVariable
CategoryNeurotrophic Factor Therapy
TargetParkinson's Disease
MechanismGDNF infusion to protect/repair dopaminergic neurons
StatusClinical Trials (Phase I/II)
TrialYear
First human trial1995
Phase I trial2002
Phase II trial2008
AspectHistorical Trials (2000s)
DeliveryContinuous infusion
TargetingPutamen
SurgicalExternal devices
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.59
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71

Related Analyses (30)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (30)

Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40

See Also (15)

LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 5 hypotheses
BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 5 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 4 hypotheses
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses

Knowledge Graph (2 edges)

ent-gene-6e1f0bee data_in benchmark_ot_ad_answer_key:GDNF
benchmark_ot_ad_answer_key:GDNF data_in ent-gene-6e1f0bee

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