| Gene Symbol | ent-gene-7b80a607 |
| Model | Finding |
| MPTP mice | Reduced dopaminergic neuron loss, improved motor function |
| 6-OHDA rats | Protected dopaminergic neurons, reduced alpha-synuclein aggregation |
| α-synuclein transgenic mice | Reduced phosphorylated α-synuclein, improved behavior |
| PINK1 knockout | Enhanced mitophagy, improved mitochondrial function |
| Combination | Rationale |
| [GLP-1 receptor agonists](/therapeutics/glp-1-receptor-agonists-parkinsons) | Complementary autophagy enhancement via different pathways |
| [Ambrioxol](/therapeutics/ambroxol-parkinsons) | Lysosomal enhancement + autophagy boost |
| [Exercise](/therapeutics/physical-exercise-parkinsons) | AMPK activation synergizes with mTOR inhibition |
| [Dietary restriction](/therapeutics/dietary-interventions-parkinsons) | Caloric restriction activates autophagy via AMPK |
| Trial | Drug |
| NCT03763955 | Sirolimus |
| RESIST-PD (planned) | Rapamycin |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |