| Gene Symbol | ent-gene-7b80a607 |
| Activators | Growth factors (via PI3K/Akt), amino acids, glucose, energy status |
| Key substrates | S6K1 (ribosomal protein S6 kinase), 4E-BP1 (eIF4E-binding protein) |
| Functions | Cytoskeletal organization, cell survival (Akt phosphorylation) |
| Rapamycin sensitivity | Generally insensitive to acute rapamycin, but chronic exposure can inhibit mTORC2 assembly |
| PI3K/Akt pathway | Growth factor signaling activates mTORC1 via TSC1/TSC2 inhibition |
| AMPK pathway | Energy stress inhibits mTORC1, linking metabolic dysfunction to autophagy regulation |
| Amino acid sensing | Rag GTPases recruit mTORC1 to lysosomal membranes for activation |
| Insulin signaling | Brain insulin resistance, common in AD, dysregulates mTOR |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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