| Gene Symbol | ent-gene-7b80a607 |
| Protein Type | Examples |
| [Autophagy](/entities/autophagy) Induction | Inhibit mTORC1 to activate ULK1 complex and initiate autophagy |
| Protein Aggregate Clearance | Enhance clearance of Aβ, tau, α-synuclein, and mutant huntingtin |
| Synaptic Plasticity | Improve LTP and memory in animal models of AD |
| Neuroinflammation | Reduce microglial activation and inflammatory cytokine production |
| Mitochondrial Function | Improve mitochondrial biogenesis and function |
| Allosteric (Rapalogs) | Rapamycin, Everolimus |
| ATP-Competitive | Torin 1, AZD8055 |
| Trial | Drug |
| NCT02955589 | Everolimus |
| NCT03763955 | Sirolimus |
| NCT04297683 | Everolimus |
| NCT04629495 | Rapamycin |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |