Contents

SYK Kinase Inhibitor Therapy for Neurodegeneration

🔬 Protein Info

Gene Symbol	ent-gene-58ffe46a
Microglial Activation	SYK mediates Aβ-induced microglial activation and cytokine production
Phagocytosis Regulation	Active SYK enhances microglial phagocytosis of amyloid plaques; suppressed SYK impairs clearance
TREM2 Signaling	SYK acts downstream of TREM2, a major AD risk gene
Synaptic Pruning	Excess SYK activity may contribute to inappropriate synaptic elimination
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph