| Gene Symbol | ent-gene-b254988d |
| Subcellular Localization | the mitochondrial outer membrane (MOM) via a single transmembrane domain at its N-terminus (residues 1-25). The catalyti |
| Step | PINK1-Parkin Action |
| Ubiquitination | Parkin adds Ub to Mfn1/2 |
| Receptor recruitment | p62 binds polyUb chains |
| Mitophagy initiation | Triggers autophagosome formation |
| Compound | Company/Group |
| Compound 9 | Denali/Celgene |
| DSN-001 | Druids/UCB |
| TH287 | BMS |
| 1-(2,6-difluorophenyl)-N-(4-sulfamoylphenyl)thiourea | Academic screen |
| USP30i-5 | Pfizer |
| Strategy | Examples |
| USP30 inhibition | Multiple programs |
| PINK1 activators | Direct activators in development |
| Parkin agonists | Small molecules |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |