| Gene Symbol | UBE2I |
| Full Name | SUMO-Conjugating Enzyme |
| Chromosome | 16p13.3 |
| Protein Type | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the brain with high levels in hippocampus, cortex, and basal ganglia |
| Molecular Weight | 18 kDa |
| UniProt ID | [P63279](https://www.uniprot.org/uniprot/P63279) |
| Ensembl ID | ENSG00000184254 |
| OMIM | 601231 |
| GeneCards | UBE2I |
| Human Protein Atlas | UBE2I |
| [Tau](/proteins/tau) | SUMOylation of tau at Lysine 340 promotes tau aggregation and formation of neurofibrillary tangles. HypoSUMOylation of tau may also contribute to toxic gain-of-function [4] |
| [APP](/entities/app-protein) | SUMOylation of amyloid precursor protein influences amyloid-beta production |
| [BACE1](/proteins/bace1) | SUMOylation of beta-secretase modulates its activity and amyloidogenesis |
| Associated Diseases | neurodegeneration |
| Interactions | ATF3 |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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