| Gene Symbol | TP53 |
| Full Name | Tumor Protein P53 |
| Chromosome | 17p13.1 |
| Function | p53 regulates cell cycle arrest, DNA repair, and apoptosis in response to cellular stress. |
| Primary Expression | all neuronal populations including: - Cortical neurons (layer 2-6) - Hippocampal neurons (CA1-CA3, dentate gyrus granule cells) - Dopaminergic neurons |
| Amino Acids | 393 aa |
| Exons | 11 |
| Pathways | Akt, Apoptosis, Autophagy, Blood-Brain Barrier, Cell Cycle |
| UniProt ID | [P04637](https://www.uniprot.org/uniprot/P04637) |
| Ensembl ID | ENSG00000141510 |
| GeneCards | TP53 |
| Human Protein Atlas | TP53 |
| N-terminal Transactivation Domain (TAD) | Residues 1-61, interacts with transcriptional coactivators (CBP/p300, MDM2) |
| Proline-Rich Domain (PRR) | Residues 64-92, contains PXXP motifs for protein-protein interactions |
| Central DNA-Binding Domain (DBD) | Residues 102-292, recognizes p53 consensus DNA response elements |
| Associated Diseases | acute myeloid leukemia, AD, adverse-risk disease, age-related illness, Aging, ALI |
| Known Drugs/Compounds | anti-cancer drugs, CHRYSOTIXINE, Emodin, Mifepristone, PC14586, PMIγ |
| Interactions | ACAT1, ACHE, ACOX1, ACSL4, ACTB, ACVR2A |
| SciDEX Hypotheses | Epigenetic Silencing of Tumor Suppressor Genes in |
| KG Connections | 2455 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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