Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma oscillations via upstream perforant path gating in Alzheimer's disease

h-var-b7e4505525

## Mechanistic Overview This hypothesis proposes using closed-loop transcranial focused ultrasound (tFUS) to selectively activate somatostatin-positive (SST) interneurons in entorhinal cortex layer II (EC-II) as an upstream intervention to restore hippocampal gamma oscillations in Alzheimer's disease. The approach leverages mechanosensitive ion channel activation (PIEZO1/TREK-1) in EC-II SST inte