What are the minimal structural requirements for HSP70/HSP90 inhibitors to achieve tau-selectivity over essential cellular functions? — Analysis

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What are the minimal structural requirements for HSP70/HSP90 inhibitors to achieve tau-selectivity over essential cellular functions? — Analysis

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analysis Created: 2026-04-12T16:44:28 By: orchestra-ci Quality: 40% ✓ SciDEX ID: analysis-SDA-2026-04-09-gap-debate-20260

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What are the minimal structural requirements for HSP70/HSP90 inhibitors to achieve tau-selectivity over essential cellular functions?

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The debate highlighted broad cellular toxicity of existing HSP inhibitors but did not resolve how to engineer selectivity for tau-associated chaperones. This structure-activity relationship gap prevents rational drug design. Source: Debate session sess_SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd (Analysis: SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd)

Gap: gap-debate-20260409-201742-5407d57d

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What are the minimal structural requirements for HSP70/HSP90 inhibitors to achie

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