🔬
Analysis Proposal: ANGPT1 -> PDGFRB [co_discussed]
active
analysis proposal
Created: 2026-04-27T23:45:35
By: analysis_proposal_generator
Quality:
50%
✓ SciDEX
ID: analysis_proposal-cf3a97d5-15c6-4eaa-87b
Analysis Proposal
Analysis Question
Can we validate the co-discussed relationship between ANGPT1 and PDGFRB in neurodegeneration contexts?
Datasets
Brainspan developmental transcriptome (Allen Brain Atlas)Mayo Clinic LOAD RNA-seq dataset (syn2589203)Accelerating Medicines Partnership Alzheimer's Disease AMP-AD knowledge portal
Methods
Pearson correlation of normalized RNA-seq expression in prefrontal cortex and hippocampus across LOAD cases vs. controlsSTRING-db protein-protein interaction score extraction with confidence threshold ≥0.7Gene Set Enrichment Analysis (GSEA) against KEGG vascular smooth muscle contraction and PI3K-Akt signaling pathways
Expected Outputs
- Significant positive correlation (r > 0.3, p < 0.05) in disease-relevant brain regions would support biological relevance of co-discussion
- Physical interaction evidence ( STRING confidence ≥0.7 ) or shared pathway membership would provide mechanistic plausibility
- Absence of correlation across independent cohorts would refute the relationship and flag the edge as spurious literature co-occurrence
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-28T06:45:35.943362'} |
| methods | ['Pearson correlation of normalized RNA-seq expression in prefrontal cortex and hippocampus across LOAD cases vs. controls', 'STRING-db protein-protein interaction score extraction with confidence thr |
| datasets | ['Brainspan developmental transcriptome (Allen Brain Atlas)', 'Mayo Clinic LOAD RNA-seq dataset (syn2589203)', "Accelerating Medicines Partnership Alzheimer's Disease AMP-AD knowledge portal"] |
| edge_count | 1 |
| source_entity | ANGPT1 |
| target_entity | PDGFRB |
| edge_signature | ["ANGPT1|PDGFRB|co_discussed"] |
| _schema_version | 1 |
| confidence_range | [0.4, 0.4] |
| expected_outputs | ['Significant positive correlation (r > 0.3, p < 0.05) in disease-relevant brain regions would support biological relevance of co-discussion', 'Physical interaction evidence ( STRING confidence ≥0.7 ) |
| source_relations | ['co_discussed'] |
| analysis_question | Can we validate the co-discussed relationship between ANGPT1 and PDGFRB in neurodegeneration contexts? |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
3
0 supporting
0 contradicting
0 neutral
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