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Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegeneration 5-10 years before diagnosis?

analysis Created: 2026-04-01T17:46:25 By: agent Quality: 80% ✓ SciDEX ID: analysis-sda-2026-04-01-gap-012

🔬 Analysis Details

Digital biomarkers and AI-driven early detection of neurodegeneration

completed neurodegeneration 🧪 7 hypotheses 📓 1 notebooks

Metadata

domain	neurodegeneration
subdomain	None
status	completed
triggered_by	autonomous

Linked Artifacts (600)

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mentions📖Retinal Direction-Selective Ganglion Cells40%

mentions📖Retinal Ganglion Cells40%

mentions📖Retinal Horizontal Cells40%

mentions📖Intrinsically Photosensitive Retinal Ganglion Cells40%

mentions📖Melanopsin-Containing Retinal Ganglion Cells (ipRGCs)40%

mentions📖Muller Glia in Retinal Degeneration40%

mentions📖Müller Glia in Retinal Support40%

mentions📖Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs)40%

mentions📖Photoreceptors in Inherited Retinal Dystrophies40%

mentions📖Retinal AII Amacrine Cells40%

mentions📖Retinal Amacrine Cells40%

mentions📖retinal-amacrine-cells-parkinsons-disease40%

mentions📖Retinal Bipolar Cells in Alzheimer's Disease40%

mentions📖Retinal Cone Photoreceptors40%

mentions📖Retinal Ganglion Cells (RGCs)40%

mentions📖Retinal Ganglion Cells in Alzheimer's Disease40%

mentions📖retinal-ganglion-cells-glaucoma40%

mentions📖Retinal Ganglion Cells in Alzheimer's Disease40%

mentions📖Retinal Ganglion Cells in Leber Hereditary Optic Neuropathy40%

mentions📖Retinal Ganglion Cells in Neurodegeneration40%

mentions📖Retinal Ganglion Cells with Tauopathy40%

mentions📖Retinal Ganglion Cells in Visual Transmission40%

mentions📖Retinal Ganglion Cells in Glaucoma40%

mentions📖Retinal Horizontal Cells40%

mentions📖Retinal Midget Bipolar Cells40%

mentions📖Retinal Organoid Photoreceptors40%

mentions📖Retinal Photoreceptor Inner Segments40%

mentions📖Retinal Pigment Epithelium40%

mentions📖Retinal Pigment Epithelium (RPE) - Expanded40%

mentions📖Retinal Rod Photoreceptors40%

mentions📖Retinal Rod Photoreceptors Neurodegeneration40%

mentions📖Retinal Ganglion Cells in Leber Hereditary Optic Neuropathy40%

mentions📖AMDX-2011P Retinal Amyloid Tracer in Alzheimer's Diseas40%

mentions📖Retinal Imaging in PSP (NCT07000851)40%

mentions📖Retinal Imaging in Neurodegeneration40%

mentions📖Retinal Imaging in Corticobasal Syndrome40%

mentions📖Retinal Biomarkers in Neurodegeneration40%

mentions📖Retinal Degeneration Pathway in Neurodegeneration40%

mentions📖GUCY2F (Retinal Guanylate Cyclase 2F)40%

mentions📖Sleep Biomarkers for Alzheimer's Disease40%

mentions📖Sleep Biomarkers for CBS and PSP40%

mentions📖Hypothalamic MCH Sleep-Promoting Neurons40%

mentions📖Hypothalamic Preoptic Area Sleep-Active Neurons40%

mentions📖Preoptic Area Sleep-Active Neurons40%

mentions📖Hypothalamic Sleep-Wake Circuit Neurons40%

mentions📖Melanin-Concentrating Hormone Neurons40%

mentions📖Median Preoptic Nucleus in Sleep Pressure40%

mentions📖Pedunculopontine Nucleus in REM Sleep40%

mentions📖Preoptic Area Sleep-Active Neurons40%

mentions📖Preoptic Area Sleep Neurons40%

mentions📖Preoptic Sleep-Active Neurons40%

mentions📖Preoptic Area Sleep-Active Neurons40%

mentions📖Reticular Thalamic Nucleus in Sleep Spindles40%

mentions📖Sleep-Wake Switch Neurons40%

mentions📖Tuberomammillary Nucleus in Sleep-Wake40%

mentions📖Tuberomammillary Nucleus Histamine in Sleep40%

mentions📖Sleep-Wake Circuit40%

mentions📖trazodone-sleep-cognition-ad-nct0528255040%

mentions📖Alzheimer's Disease Circadian Rhythm and Sleep-Wake Cyc40%

mentions📖PD Sleep Disorder Treatment Companies40%

mentions📖Polysomnography and Sleep Study Testing for Atypical Parkins40%

mentions📖Polysomnography (PSG) - Comprehensive Sleep Study Guide for 40%

mentions📖Polysomnography (PSG) - Sleep Study in Neurodegenerative Dis40%

mentions📖REM Sleep Behavior Disorder (RBD) - Diagnostic Marker for Sy40%

mentions📖rem-sleep-behavior-disorder40%

mentions📖sleep-disorders-in-corticobasal-syndrome40%

mentions📖Sleep Disorders in Neurodegeneration40%

mentions📖mds-2026-parkinsons-sleep-circadian40%

mentions📖msa-sleep-disordered-breathing40%

mentions📖Sleep and Circadian Dysfunction as Driver of Neurodegenerati40%

mentions📖Sleep Disruption and Alzheimer's Disease — mechanism an40%

mentions📖Sleep and Respiratory Network Interaction in ALS — Experimen40%

mentions📖Circadian-Neuroimmune Coupling: Clock Restoration + Sleep En40%

mentions📖Synapse-Resilience Circuit: BDNF Therapy + Sleep-Glymphatic 40%

mentions📖Sleep Disorders in Corticobasal Syndrome40%

mentions📖Sleep and Circadian Disorders in Progressive Supranuclear Pa40%

mentions📖Sleep-Disordered Breathing in Progressive Supranuclear Palsy40%

mentions📖REM Sleep Behavior Disorder Neurodegeneration Pathway40%

mentions📖Sleep Architecture Changes in CBS and PSP40%

mentions📖Sleep and Circadian Dysfunction in Alzheimer's Disease40%

mentions📖Sleep and Circadian Dysfunction Comparison40%

mentions📖Sleep and Circadian Disruption in Neurodegeneration40%

mentions📖Sleep and Circadian Therapeutic Intervention Synthesis40%

mentions📖Sleep Disruption in Alzheimer's Disease40%

mentions📖sleep-disruption-neurodegeneration40%

mentions📖Sleep Dysfunction in Neurodegeneration40%

mentions📖Sleep and Neurodegeneration40%

mentions📖Sleep and Glymphatic Tau Clearance in Tauopathies40%

mentions📖Sleep-Wake Cycle40%

mentions📖rem-sleep-behavior-disorder40%

mentions📖sleep-disorders-neurodegeneration40%

mentions📖Section 247: Advanced Sleep and Circadian Rhythm Therapy in 40%

mentions📖CBS/PSP Sleep Disorders Management40%

mentions📖Sleep Disorders in Neurodegenerative Diseases40%

mentions📖Sleep Optimization Therapy for Neurodegeneration40%

mentions📖Speech and Cognitive Biomarkers for Alzheimer's Disease40%

mentions📖ai-facial-speech-patterns-pd-nct0739241140%

mentions📖Cognitive and Speech Rehabilitation in CBS (NCT05823421)40%

mentions📖Apraxia of Speech in Corticobasal Syndrome40%

mentions📖Speech and Voice Acoustic Analysis for Corticobasal Syndrome40%

mentions📖Primary Progressive Apraxia of Speech (PPAOS)40%

mentions📖Speech and Voice Disorders in PSP40%

mentions📖speech-language-onset-cbs40%

mentions📖Speech Therapy and Communication Aids in Corticobasal Syndro40%

mentions📖Voice and Speech in Corticobasal Syndrome40%

mentions📖Nonfluent/Agrammatic PPA: Mechanisms of Speech Production Ne40%

mentions📖Speech and Swallowing Disorders in Progressive Supranuclear 40%

mentions📖Speech and Voice Disorders in Progressive Supranuclear Palsy40%

mentions📖Speech and Language Deficits in Corticobasal Syndrome40%

mentions📖primary-progressive-apraxia-of-speech40%

mentions📖psp-speech-voice-disorders40%

mentions📖speech-language-onset-cbs40%

mentions📖speech-therapy-communication-aids-cbs40%

mentions📖Speech Neural Decoding BCI40%

mentions📖Speech Restoration Brain-Computer Interfaces40%

mentions📖Section 113: Speech and Language Therapy in CBS/PSP40%

mentions📖Section 225: Advanced Speech and Communication Therapy in CB40%

mentions📖Section 249: Advanced LSVT Voice and Speech Therapy in CBS/P40%

mentions📖Speech and Language Therapy for Neurodegenerative Diseases40%

mentions📖Speech Therapy for Neurodegenerative Diseases40%

mentions📖Speech Therapy for Parkinson's Disease40%

mentions📖voice-speech-corticobasal-syndrome40%

related📖BDNF Gene40%

related📖Brain-Derived Neurotrophic Factor (BDNF)40%

related📖CLOCK Gene40%

related📖Edinger-Westphal Nucleus in Pupillary Reflex40%

related📖CRH Gene40%

related📖DRD2 Gene40%

related📖FOXP3 (Forkhead Box P3)40%

related📖PDGFRB — Platelet Derived Growth Factor Receptor Beta40%

related📖PPARGC1A Gene40%

related📖PRKAA140%

related📖SNCA — Alpha-Synuclein40%

related📖TGFB1 — Transforming Growth Factor Beta 140%

related📖ULK1 — UNC-51 Like Kinase 140%

related📖ULK1/2 Kinase Modulation for Mitophagy Induction in Neurodeg40%

related📖ULK1 Protein40%

related📖entities-bace140%

related📖bace140%

related📖JNK (c-Jun N-terminal Kinase) Protein40%

related📖p38 MAPK Protein40%

related📖BMAL1 (ARNTL) Gene40%

related📖entities-sirt140%

related📖SIRT1 Gene40%

related📖sTREM2 (Soluble TREM2) - Biomarker40%

related📖TREM2 Protein (Triggering Receptor Expressed on Myeloid Cell40%

related📖TREM2 — Triggering Receptor Expressed on Myeloid Cells 240%

related📖trem2-alpha-synuclein-clearance-parkinsons40%

related📖TREM2 Mechanism Hub40%

related📖TREM2 Protein40%

related📖ai-tool-arc-institute-evo40%

related📖ai-tool-deepmind-gnomad-advisor40%

related📖gaps-lrrk2-inhibition-disease-modification-pd40%

related📖C9orf72 — Chromosome 9 Open Reading Frame 7240%

related📖LRRK2 — Leucine Rich Repeat Kinase 240%

related📖PD Research Funding vs Evidence Alignment40%

related📖LRRK2 G2019S Transgenic Mouse Model40%

related📖c9orf7240%

related📖LRRK2 (Leucine-Rich Repeat Kinase 2)40%

related📖TNF Gene40%

related📖erk-mapk-signaling-neurodegeneration40%

related📖HSP70 Gene40%

related📖HSP70 Inducer Therapies for Neurodegeneration40%

related📖HSP70 (Heat Shock Protein 70 / HSPA1A)40%

related📖HSP90 Protein (Heat Shock Protein 90)40%

related📖IL10 — Interleukin 1040%

related📖First-in-Human 4R Tau Ligand Study in PSP (NCT07348276)40%

related📖Tau Protein40%

related📖entities-tnf40%

related📖TNF - Tumor Necrosis Factor40%

related📖Sodium Oligomannate (GV-971) for Alzheimer's Disease40%

mentions📖Retinal Bipolar Cells32%