concept

ANGPT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANGPT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

372Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

ANGPT1 is a concept in neurodegeneration research. Key relationships include: activates, co discussed, associated with. Associated with ALS, Als, Arthritis. Connected to 85 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ANGPT1
Related Diseases	vascular barrier function, Vascular Permeability, Vascular Barrier Function
Related Pathways	Angiogenesis-Related Pathway, PI3K/AKT Pathway

🔮 Predicted Structure: ANGPT1 — AlphaFold E5RFF4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ANGPT1["ANGPT1"]
    ANGPT1 -->|"expressed in"| Pericyte_Derived_Extracellular["Pericyte-Derived Extracellular Vesicles"]
    ANGPT1 -->|"regulates"| Vascular_Permeability["Vascular Permeability"]
    ANGPT1 -->|"activates"| PI3K_AKT_Pathway["PI3K/AKT Pathway"]
    ANGPT1 -->|"regulates"| Intestinal_Barrier_Function["Intestinal Barrier Function"]
    ANGPT1 -->|"downregulates"| Inflammatory_Cytokines["Inflammatory Cytokines"]
    ANGPT1 -->|"activates"| Als["Als"]
    ANGPT1 -->|"activates"| Cancer["Cancer"]
    ANGPT1 -->|"activates"| Ms["Ms"]
    ANGPT1 -->|"activates"| Tumor["Tumor"]
    ANGPT1 -->|"activates"| Arthritis["Arthritis"]
    h_35f04e1b["h-35f04e1b"] -->|"targets"| ANGPT1
    BMP2["BMP2"] -->|"activates"| ANGPT1
    VEGF["VEGF"] -->|"activates"| ANGPT1
    FGF2["FGF2"] -->|"activates"| ANGPT1
    CD8["CD8"] -->|"activates"| ANGPT1
    VEGFB["VEGFB"] -->|"activates"| ANGPT1
    RUNX2["RUNX2"] -->|"activates"| ANGPT1
    PDGFRB["PDGFRB"] -->|"activates"| ANGPT1
    GENES["GENES"] -->|"activates"| ANGPT1
    PI3K["PI3K"] -->|"activates"| ANGPT1

Outgoing (276)

Target	Relation	Type	Str
Pericyte-Derived Extracellular Vesicles	expressed_in	cell_type	0.95
Vascular Barrier Function	associated_with	process	0.95
vascular barrier function	promotes	phenotype	0.95
Pericyte-Derived Extracellular Vesicles	component_of	compound	0.92
Vascular Permeability	regulates	phenotype	0.90
Vascular Barrier Function	contributes_to	process	0.90
Vascular Barrier Function	activates	phenotype	0.90
Angiogenesis-Related Pathway	involved_in	pathway	0.90
PI3K/AKT Pathway	activates	pathway	0.85
Pericyte Recruitment	regulates	process	0.85
Pericyte Recruitment	mediates	process	0.85
Intestinal Barrier Function	protects_against	phenotype	0.85
vascular endothelial cell proliferation	promotes	process	0.85
Angiogenesis	promotes	process	0.85
Intestinal Barrier Function	regulates	phenotype	0.80
Intestinal Barrier Function	associated_with	phenotype	0.80
Pericyte Recruitment	promotes	process	0.80
Sepsis	treats	disease	0.80
Inflammatory Cytokines	downregulates	biomarker	0.75
Sepsis	associated_with	disease	0.70
Arthritis	activates	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Sepsis	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
ALS	activates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Ischemia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	causes	disease	0.65
Als	causes	disease	0.65
Ischemia	activates	disease	0.65
Diabetes	inhibits	disease	0.65
Obesity	activates	disease	0.65
ALS	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Carcinoma	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
ALS	causes	disease	0.65
Inflammation	activates	disease	0.65
PDGFRB	activates	gene	0.60
VEGFB	activates	gene	0.60

Incoming (96)

Source	Relation	Type	Str
Pericyte-derived Extracellular Vesicles	component_of	structure	0.90
Pericyte-derived Extracellular Vesicles	associated_with	cell_type	0.90
Pericyte-Derived Extracellular Vesicles	transports	cell_type	0.90
h-35f04e1b	targets_gene	hypothesis	0.90
Pericyte-Derived Extracellular Vesicles	associated_with	cell_type	0.85
STING	upregulates	protein	0.85
h-35f04e1b	targets	hypothesis	0.80
BMP2	activates	gene	0.60
VEGF	activates	gene	0.60
FGF2	activates	gene	0.60
CD8	activates	gene	0.60
PDGFRB	associated_with	gene	0.60
VEGFB	activates	gene	0.60
PDGFRB	activates	gene	0.60
PI3K	activates	gene	0.60
STING	activates	gene	0.60
AKT	activates	gene	0.60
BCL2L1	associated_with	gene	0.60
MAP2K1	associated_with	gene	0.60
AKT	associated_with	entity	0.60
GJA1	associated_with	gene	0.60
VCAM1	associated_with	gene	0.60
CD44	associated_with	gene	0.60
AKT	inhibits	gene	0.60
PIK3R1	inhibits	gene	0.60
AHR	activates	gene	0.60
NOTCH3	activates	gene	0.60
CLDN5	inhibits	gene	0.60
PPAR	expressed_in	gene	0.60
VEGF	expressed_in	gene	0.60
TAU	causes	gene	0.60
HDAC2	activates	gene	0.60
UCHL1	activates	gene	0.60
RUNX2	activates	gene	0.60
GENES	activates	gene	0.60
PERICYTE	interacts_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
CANCER	activates	gene	0.60
CCL2	associated_with	gene	0.60
HDAC	activates	gene	0.60
DEMENTIA	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
GENES	inhibits	gene	0.60
AREG	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
YAP	activates	gene	0.60
HIF-1Α	activates	gene	0.60
GENES	associated_with	gene	0.60
WNT	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ANGPT1

Understanding Entity Pages

Summary

Wiki Pages (20)

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