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TFAM and mtDNA analysis in AKI patients

experiment Created: 2026-04-10 14:43:05 By: experiment_extractor Quality: 80% ✓ SciDEX ID: experiment-exp-2c1e614a-ea00-4166-91ea-b
🧫 Experiment Protocol Clinical
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Related Entities
TFAM
Metadata
experiment_typeclinical
protocolAnalysis of kidney biopsy or tissue samples from AKI patients using immunohistochemistry and/or molecular techniques to assess TFAM expression and mtDNA nucleoid structure
expected_outcomesAKI patients would show reduced TFAM levels and damaged mtDNA nucleoids similar to experimental models
success_criteriaDemonstrable loss of TFAM and mtDNA damage in human AKI kidney samples
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T07:43:05.743205
source_pmid33408785
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T14:43:05.827568'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (73)
derives_from📄Mitochondrial ROS promote mitochondrial dysfunction and infl100%
related🧫IRI-AKI mouse model with mtROS inhibition100%
related🧫mtROS effects on TFAM and mtDNA in HK2 cells100%
related🧫TFAM knockdown functional analysis100%
related🧪TFAM overexpression creates mitochondrial donor-recipient gr100%
mentions📖DNA Methylation Biomarkers in Neurodegeneration70%
mentions📖DNA Damage-Accumulating Neurons in Neurodegeneration70%
mentions📖DNA Damage and Repair in Neurons70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Methylation70%
mentions📖DNA Damage Repair Deficiency Validation Study in Parkinson&#70%
mentions📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 70%
mentions📖DNA Damage Repair Therapy - Biomarker Guided70%
mentions📖DNA Damage Repair Investment Landscape70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖dna-damage-repair70%
mentions📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas70%
mentions📖DNA Damage Response Impairment Pathway70%
mentions📖DNA Damage Response in 4R-Tauopathies70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Damage Response and Repair in Neurodegeneration70%
mentions📖DNA Damage Response in Neurons70%
mentions📖DNA Damage Response in Parkinson's Disease70%
mentions📖DNA Damage Response in Neurodegeneration70%
mentions📖DNA Methylation in Neurodegeneration70%
mentions📖DNA Repair Mechanisms in Neurodegeneration70%
mentions📖DNA Sensing Pathways in Neurodegeneration70%
mentions📖DNA Damage and Repair Dysfunction in PSP70%
mentions📖DNA Ligase III Protein70%
mentions📖DNA Ligase IV Protein70%
mentions📖DNA-PKcs (PRKDC) Protein70%
mentions📖DNA Damage Repair Therapy for Neurodegeneration70%
mentions📖DNA Repair Therapy for Neurodegeneration70%
mentions📖TFAM Gene70%
mentions📖TFAM Protein70%
related📖DNA Methylation Biomarkers in Neurodegeneration63%
related📖DNA Damage-Accumulating Neurons in Neurodegeneration63%
related📖DNA Damage and Repair in Neurons63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Methylation63%
related📖DNA Damage Repair Deficiency Validation Study in Parkinson&#63%
related📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 63%
related📖DNA Damage Repair Therapy - Biomarker Guided63%
related📖DNA Damage Repair Investment Landscape63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖dna-damage-repair63%
related📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas63%
related📖DNA Damage Response Impairment Pathway63%
related📖DNA Damage Response in 4R-Tauopathies63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Damage Response and Repair in Neurodegeneration63%
related📖DNA Damage Response in Neurons63%
related📖DNA Damage Response in Parkinson's Disease63%
related📖DNA Damage Response in Neurodegeneration63%
related📖DNA Methylation in Neurodegeneration63%
related📖DNA Repair Mechanisms in Neurodegeneration63%
related📖DNA Sensing Pathways in Neurodegeneration63%
related📖DNA Damage and Repair Dysfunction in PSP63%
related📖DNA Ligase III Protein63%
related📖DNA Ligase IV Protein63%
related📖DNA-PKcs (PRKDC) Protein63%
related📖DNA Damage Repair Therapy for Neurodegeneration63%
related📖DNA Repair Therapy for Neurodegeneration63%
related📖TFAM Gene63%
related📖TFAM Protein63%
mentions📖Mitochondria60%
related🧪TFAM overexpression creates mitochondrial donor-recipient gr60%
related📓Nutrient-Sensing Epigenetic Circuit Reactivation — Computati60%
related📓Aging Mouse Brain Atlas: Cross-Age Gene Expression Analysis60%
related📖Mitochondria54%
related📓Aging Mouse Brain Atlas: Cross-Age Gene Expression Analysis20%