🧫

Amyloid plaque load analysis in triple-mutant mouse brains

experiment Created: 2026-04-10 22:32:02 By: experiment_extractor Quality: 88% ✓ SciDEX ID: experiment-exp-4c97be59-973e-4997-bca9-8
🧫 Experiment Protocol Neuropathology
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Metadata
experiment_typeneuropathology
protocolBrain tissue harvesting, histological processing, amyloid plaque staining and quantification, neuropathology assessment
expected_outcomesDramatic reduction in amyloid plaque formation and associated neuropathology
success_criteriaAlmost complete elimination of aggregated and unaggregated Abeta
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T15:32:02.705344
source_pmid18258340
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T22:32:02.778399'}
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Linked Artifacts (77)
related🧫Behavioral assessment of APP/PSEN1/GD3S triple-mutant mice100%
related🧫Abeta-induced cell death and aggregation in GD3S-deficient n100%
mentions📖APP-Overexpressing Neurons70%
mentions📖APP Arctic Mutation (APP Arctic)70%
mentions📖APP Dutch Mutation (APP Dutch)70%
mentions📖APP Flemish Mutation (APP Flemish)70%
mentions📖APP Swedish Mutation (APPswe)70%
mentions📖APP Gene70%
mentions📖app70%
mentions📖APP Gene Dosage Reduction Therapy for Down Syndrome70%
mentions📖APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chai70%
mentions📖APP Amyloid Pathway in Alzheimer's Disease70%
mentions📖APP-BACE1-Fe65 Complex70%
mentions📖APP Processing and Amyloid-Beta Production70%
mentions📖APP/PS1 Double Transgenic Mouse Model70%
mentions📖APP/PS1 Dual Transgenic Mouse Model70%
mentions📖APP Protein70%
mentions📖PSEN1-Mutant Neurons70%
mentions📖PSEN1 Mutations in Alzheimer's Disease70%
mentions📖entities-psen170%
mentions📖PSEN1 — Presenilin 170%
mentions📖PSEN1 Presenilin 1 AD Causal Chain70%
mentions📖PSEN1 Protein (Presenilin-1)70%
related📖APP-Overexpressing Neurons63%
related📖APP Arctic Mutation (APP Arctic)63%
related📖APP Dutch Mutation (APP Dutch)63%
related📖APP Flemish Mutation (APP Flemish)63%
related📖APP Swedish Mutation (APPswe)63%
related📖APP Gene63%
related📖app63%
related📖APP Gene Dosage Reduction Therapy for Down Syndrome63%
related📖APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chai63%
related📖APP Amyloid Pathway in Alzheimer's Disease63%
related📖APP-BACE1-Fe65 Complex63%
related📖APP Processing and Amyloid-Beta Production63%
related📖APP/PS1 Double Transgenic Mouse Model63%
related📖APP/PS1 Dual Transgenic Mouse Model63%
related📖APP Protein63%
related📖PSEN1-Mutant Neurons63%
related📖PSEN1 Mutations in Alzheimer's Disease63%
related📖entities-psen163%
related📖PSEN1 — Presenilin 163%
related📖PSEN1 Presenilin 1 AD Causal Chain63%
related📖PSEN1 Protein (Presenilin-1)63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
mentions📖Neurodegeneration60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖Neurodegeneration54%
mentions📖Ganglioside and Membrane Lipid Raft Dysfunction in 4R-Tauopa50%
mentions📖gd3-synthase50%
mentions📖Sphingolipid Metabolism Dysregulation in 4R-Tauopathies44%
mentions📖Memory Prosthetic BCI for Alzheimer's Disease44%