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GWAS meta-analysis of major depressive disorder across three cohorts

experiment Created: 2026-04-06 12:30:40 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-5f1ec586-f80a-4c02-9641-6
🧫 Experiment Protocol Genetic Association
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Metadata
experiment_typegenetic_association
protocolGenome-wide association analysis followed by meta-analysis across three cohorts with different case ascertainment methods. Statistical analysis using standard GWAS methodology with genome-wide signifi
expected_outcomesIdentification of novel genetic loci associated with MDD risk
success_criteriaP < 5 × 10^-8 for genome-wide significance
sample_size336753
statistical_methodsmeta-analysis, genome-wide association testing
p_value5e-08
effect_sizeNone
extracted_at2026-04-06T05:30:40.929261
source_pmid29728651
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:30:40.932405'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (26)
derives_from📄Common variants on 6q16.2, 12q24.31 and 16p13.3 are associat100%
mentions📖GWAS Findings Hub70%
mentions📖GWAS Findings Hub: Alzheimer's and Parkinson's Dis70%
mentions📖PGC-1α Mitochondrial Biogenesis Comparison — AD/PD/ALS/FTD/H70%
mentions📖PGC-1α and Mitochondrial Biogenesis Therapies for Parkinson&70%
mentions📖PGC-1α Protein70%
mentions📖proteins-pgc-1a-protein70%
mentions📖PGC-1α (PPARGC1A)70%
mentions📖PGC-1 Alpha70%
mentions📖PGC-1β Protein70%
mentions📖PGC-1α Activator Therapy for Neurodegeneration70%
mentions📖PGC-1α (PPARGC1A) Targeted Therapies in Neurodegeneration70%
related📖GWAS Findings Hub63%
related📖GWAS Findings Hub: Alzheimer's and Parkinson's Dis63%
related📖PGC-1α Mitochondrial Biogenesis Comparison — AD/PD/ALS/FTD/H63%
related📖PGC-1α and Mitochondrial Biogenesis Therapies for Parkinson&63%
related📖PGC-1α Protein63%
related📖proteins-pgc-1a-protein63%
related📖PGC-1α (PPARGC1A)63%
related📖PGC-1 Alpha63%
related📖PGC-1β Protein63%
related📖PGC-1α Activator Therapy for Neurodegeneration63%
related📖PGC-1α (PPARGC1A) Targeted Therapies in Neurodegeneration63%
mentions📖Depression (Major Depressive Disorder)60%
related📖Depression (Major Depressive Disorder)60%
related📖Depression (Major Depressive Disorder)54%