PGC-1 Alpha

PGC-1 Alpha

Introduction

Pgc 1 Alpha is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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<div class="infobox infobox-protein">
|+ PGC-1 Alpha
! Protein Name
| PGC-1 Alpha
! Gene
| [PPARGC1A](/genes/ppargc1a)
! UniProt ID
| [Q9UBX3](https://www.uniprot.org/uniprot/Q9UBX3)
! PDB IDs
| 1X8J, 3B9I
! Molecular Weight
| 91.2 kDa
! Subcellular Localization
| Nucleus, Mitochondrion
! Protein Family
| PGC-1 family
</div>

Overview

PGC-1 Alpha (PPARGC1A) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

PGC-1alpha has multiple activation domains and interacts with many transcription factors.

Normal Function

PGC-1alpha is a transcriptional coactivator that regulates mitochondrial biogenesis, oxidative metabolism, and antioxidant responses. It activates NRF-1, NRF-2, and ERR-alpha to drive mitochondrial gene expression.

Role in Disease

PGC-1alpha dysfunction is implicated in Parkinson's disease, Huntington's disease, and ALS. Exercise induces PGC-1alpha.

Therapeutic Targeting

PGC-1 Alpha

Introduction

Pgc 1 Alpha is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

.infobox .infobox-protein
{
float: right;
width: 300px;
padding: 10px;
background: #f8f9fa;
border: 1px solid #ddd;
border-radius: 4px;
margin: 10px;
}

.infobox .infobox-protein th
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background: #28a745;
color: white;
padding: 8px;
}

.infobox .infobox-protein td
{
padding: 6px;
}

<div class="infobox infobox-protein">
|+ PGC-1 Alpha
! Protein Name
| PGC-1 Alpha
! Gene
| [PPARGC1A](/genes/ppargc1a)
! UniProt ID
| [Q9UBX3](https://www.uniprot.org/uniprot/Q9UBX3)
! PDB IDs
| 1X8J, 3B9I
! Molecular Weight
| 91.2 kDa
! Subcellular Localization
| Nucleus, Mitochondrion
! Protein Family
| PGC-1 family
</div>

Overview

PGC-1 Alpha (PPARGC1A) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

PGC-1alpha has multiple activation domains and interacts with many transcription factors.

Normal Function

PGC-1alpha is a transcriptional coactivator that regulates mitochondrial biogenesis, oxidative metabolism, and antioxidant responses. It activates NRF-1, NRF-2, and ERR-alpha to drive mitochondrial gene expression.

Role in Disease

PGC-1alpha dysfunction is implicated in Parkinson's disease, Huntington's disease, and ALS. Exercise induces PGC-1alpha.

Therapeutic Targeting

No direct PGC-1alpha drugs. Exercise and AMPK activators (metformin) enhance PGC-1alpha activity.

Background

The study of Pgc 1 Alpha has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

Pathway & Interaction Diagram

Interactive diagram showing PPARGC1A's key relationships in the SciDEX knowledge graph (15 connections shown).

References

References

• Lin J et al. (2004) Transcriptional co-activator PGC-1alpha. Cell 119(1):5-7. PMID: 15620178(https://pubmed.ncbi.nlm.nih/15620178/)
• Handschin C et al. (2007) The biology of PGC-1alpha. Physiol Rev 87(2):367-398. PMID: 17446436(https://pubmed.ncbi.nlm.nih/17446436/)
• Luo Y et al. (2019) PGC-1alpha in neurodegenerative diseases. Mol Neurobiol 56(5):3610-3624. PMID: 30117104(https://pubmed.ncbi.nlm.nih/30117104/)
• Chaturvedi RK et al. (2009) PGC-1alpha in Parkinson's disease. J Neurochem 110(3):857-868. PMID: 19457121(https://pubmed.ncbi.nlm.nih/19457121/)
• Wrann CD et al. (2013) Exercise induces PGC-1alpha in the brain. J Neurosci 33(1):195-207. PMID: 23283329(https://pubmed.ncbi.nlm.nih/23283329/)
• Katsouri L et al. (2020) PGC-1alpha and mitochondrial function. Neuropharmacology 175:108158. PMID: 32461084(https://pubmed.ncbi.nlm.nih/32461084/)
• Mudò G et al. (2012) PGC-1alpha in neuroprotection. Cell Death Dis 3:e285. PMID: 22258406(https://pubmed.ncbi.nlm.nih/22258406/)
• Jiang H et al. (2021) PGC-1alpha in ALS. Acta Neuropathol Commun 9(1):139. PMID: 34376275(https://pubmed.ncbi.nlm.nih/34376275/)

References

References

• Lin J et al. (2004) Transcriptional co-activator PGC-1alpha. Cell 119(1):5-7. PMID: 15620178(https://pubmed.ncbi.nlm.nih/15620178/)
• Handschin C et al. (2007) The biology of PGC-1alpha. Physiol Rev 87(2):367-398. PMID: 17446436(https://pubmed.ncbi.nlm.nih/17446436/)
• Luo Y et al. (2019) PGC-1alpha in neurodegenerative diseases. Mol Neurobiol 56(5):3610-3624. PMID: 30117104(https://pubmed.ncbi.nlm.nih/30117104/)
• Chaturvedi RK et al. (2009) PGC-1alpha in Parkinson's disease. J Neurochem 110(3):857-868. PMID: 19457121(https://pubmed.ncbi.nlm.nih/19457121/)
• Wrann CD et al. (2013) Exercise induces PGC-1alpha in the brain. J Neurosci 33(1):195-207. PMID: 23283329(https://pubmed.ncbi.nlm.nih/23283329/)
• Katsouri L et al. (2020) PGC-1alpha and mitochondrial function. Neuropharmacology 175:108158. PMID: 32461084(https://pubmed.ncbi.nlm.nih/32461084/)
• Mudò G et al. (2012) PGC-1alpha in neuroprotection. Cell Death Dis 3:e285. PMID: 22258406(https://pubmed.ncbi.nlm.nih/22258406/)
• Jiang H et al. (2021) PGC-1alpha in ALS. Acta Neuropathol Commun 9(1):139. PMID: 34376275(https://pubmed.ncbi.nlm.nih/34376275/)

See Also

• -

• External Links

• [UniProt: Q9UBK2](https://www.uniprot.org/uniprot/Q9UBK2)
• [NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/)