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CHI3L1 variant association with AD progression in human patients

experiment Created: 2026-04-10 22:32:22 By: experiment_extractor Quality: 85% ✓ SciDEX ID: experiment-exp-73e6f43d-a179-4e2d-955a-a
🧫 Experiment Protocol Genetic Association
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Related Entities
CHI3L1
Metadata
experiment_typegenetic_association
protocolGenetic variant analysis in AD patient cohort with CSF YKL-40 measurements
expected_outcomesVariants decreasing YKL-40 expression associated with slower AD progression
success_criteriaSignificant association between CHI3L1 variants and progression rates
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T15:32:22.434606
source_pmid33328329
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T22:32:22.438537'}
🌍 Provenance Graph 1 nodes, 0 edges

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Linked Artifacts (51)
related🧫Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's d100%
related🧫Chi3l1 deletion effects on baseline glial activation in mice100%
mentions📖CHI3L1 Gene70%
mentions📖CHI3L1 Protein (YKL-40)70%
mentions📖YKL-40 (Chitinase 3-Like 1)70%
mentions📖YKL-40 (CHI3L1) - Biomarker70%
mentions📖YKL-40 (Chitinase-3-like protein 1)70%
mentions📖YKL-40-Targeted Anti-Inflammatory Therapy for Neurodegenerat70%
mentions📖YKL-40 Anti-Inflammatory Cycling70%
mentions📖YKL-40 Protein70%
related📖CHI3L1 Gene63%
related📖CHI3L1 Protein (YKL-40)63%
related📖YKL-40 (Chitinase 3-Like 1)63%
related📖YKL-40 (CHI3L1) - Biomarker63%
related📖YKL-40 (Chitinase-3-like protein 1)63%
related📖YKL-40-Targeted Anti-Inflammatory Therapy for Neurodegenerat63%
related📖YKL-40 Anti-Inflammatory Cycling63%
related📖YKL-40 Protein63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
related📖Alzheimer's Disease60%
related📖neuroinflammation55%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
mentions📖VILIP-1 and YKL-40 - Alzheimer's Disease Biomarkers50%
mentions📖Microglial Activation Biomarker Panel for Neurodegenerative 44%
mentions📖Advanced Proteomics and Protein Biomarker Panels in CBS/PSP44%