📖

CHI3L1 Gene

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-chi3l1

Related Entities

Metadata

slug	genes-chi3l1
entity_type	gene
kg_node_id	CHI3L1

🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

Linked Artifacts (60)

mentions🧫Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's d80%

mentions🧫Chi3l1 deletion effects on baseline glial activation in mice80%

related🧫Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's d72%

related🧫Chi3l1 deletion effects on baseline glial activation in mice72%

mentions🧫CHI3L1 variant association with AD progression in human pati70%

mentions🧫Experiment: Autoimmune Hypothesis Testing in AD70%

related🧫CHI3L1 variant association with AD progression in human pati63%

related🧫Experiment: Autoimmune Hypothesis Testing in AD63%

see_also📖Apoptosis in Neurodegeneration60%

see_also📖AQP4 (Aquaporin-4 Gene)60%

see_also📖HBA1 Gene60%

see_also📖HBB Gene60%

see_also📖MMP3 Gene60%

see_also📖tnfaip660%

see_also📖Alzheimer Indonesia60%

see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%

see_also📖CHIT1 Gene (Chitinase 1)60%

see_also📖NPTX1 — Neuronal Pentraxin 160%

see_also📖NPTX1 Protein60%

see_also📖Amyloid-Related Imaging Abnormalities (ARIA)60%

see_also📖IL4 Gene60%

see_also📖IL9 (Interleukin 9)60%

see_also📖MDH1 — Malate Dehydrogenase 160%

see_also📖NEFL — Neurofilament Light Chain60%

see_also📖hypotheses-apoe-contributes-alzheimers-disease-regulat60%

see_also📖RORC Gene60%

see_also📖APP Gene Dosage Reduction Therapy for Down Syndrome60%

mentions🧪Metabolic Circuit Breaker via Lipid Droplet Modulation50%

mentions🧫Experiment: Autoimmune Hypothesis Testing in AD50%

mentions🧪Metabolic Circuit Breaker via Lipid Droplet Modulation50%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪Glymphatic System-Enhanced Antibody Clearance Reversal50%

mentions🧪SASP-Driven Aquaporin-4 Dysregulation50%

mentions🧪Aquaporin-4 Polarization Rescue50%

mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%

mentions🧪Temporal Decoupling via Circadian Clock Reset50%

mentions🧪Circadian Clock-Autophagy Synchronization50%

mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%

mentions🧪Pericyte Contractility Reset via Selective PDGFR-β Agonism50%

mentions🧪CYP46A1 Overexpression Gene Therapy50%

mentions🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th50%

related🔬What are the mechanisms underlying microglia-astrocyte cross50%

related🔬What are the mechanisms underlying neuroinflammation resolut50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬What are the mechanisms underlying microglia-astrocyte cross50%

related🔬What are the mechanisms underlying neuroinflammation resolut50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

related🔬What are the mechanisms underlying sleep disruption as cause50%

related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪CYP46A1 Overexpression Gene Therapy40%

related🧪Metabolic Circuit Breaker via Lipid Droplet Modulation40%

related🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th40%

mentions🔬What are the mechanisms underlying microglia-astrocyte cross35%