protein

CHI3L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHI3L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

361Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

CHI3L1 (Chitinase 3-like Protein 1), also known as YKL-40, is a secreted glycoprotein implicated in neuroinflammation and neurodegenerative diseases including Alzheimer's and Parkinson's.

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🔬 Protein Info

Gene Symbol	YKL
Full Name	40 (CHI3L1) - Biomarker
Aliases	CHI3L1
Chromosome	1q32.1
Function	YKL-40, also known as chitinase 3-like protein 1 (CHI3L1), is a secreted glycoprotein belonging to the glycoside hydrolase family 18[@chitinase2020].
GeneCards	YKL
Human Protein Atlas	YKL
Cutoff values differ by population	Japanese studies suggest 90 ng/mL CSF cutoff vs. 80 ng/mL for Western cohorts
APOE ε4 interaction	YKL-40 elevation more pronounced in APOE ε4 carriers across all Asian populations
Vascular comorbidity	Higher baseline YKL-40 in subjects with small vessel disease (common in East Asian populations)
Associated Diseases	Als, Alzheimer, Fibrosis, Inflammation, Neuroinflammation, neurodegeneration
Known Drugs/Compounds	hygromycin B
Interactions	AQP4, GBM, STAT3, RAGE, APP, JAK1
SciDEX Hypotheses	Integrated Biomarker Panel for Therapeutic Window
KG Connections	360 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: CHI3L1 — AlphaFold P36222 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHI3L1["CHI3L1"]
    CHI3L1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CHI3L1 -->|"expressed in"| Inflammation["Inflammation"]
    CHI3L1 -->|"expressed in"| Neuroinflammation["Neuroinflammation"]
    CHI3L1 -->|"contributes to"| Aging["Aging"]
    CHI3L1 -->|"activates"| Autoimmune["Autoimmune"]
    CHI3L1 -.biomarker for.-> Als["Als"]
    CHI3L1 -.biomarker for.-> Alzheimer["Alzheimer"]
    CHI3L1 -->|"regulates"| Glioblastoma["Glioblastoma"]
    CHI3L1 -->|"inhibits"| Tumor["Tumor"]
    STAT3["STAT3"] -->|"regulates"| CHI3L1
    IL9["IL9"] -.biomarker for.-> CHI3L1
    IL4["IL4"] -.biomarker for.-> CHI3L1
    FGF2["FGF2"] -.biomarker for.-> CHI3L1
    GFAP["GFAP"] -.biomarker for.-> CHI3L1
    MDH1["MDH1"] -.biomarker for.-> CHI3L1
    SQSTM1["SQSTM1"] -.biomarker for.-> CHI3L1
    BDNF["BDNF"] -.biomarker for.-> CHI3L1
    APOE["APOE"] -.biomarker for.-> CHI3L1
    NEFL["NEFL"] -.biomarker for.-> CHI3L1

Outgoing (268)

Target	Relation	Type	Str
Hippocampal Neurogenesis	inhibits	process	0.95
STAT3	binds_to	protein	0.95
YKL-40	encodes	protein	0.95
Neuroinflammation	involved_in	process	0.95
Astrocytes	expressed_in	cell_type	0.95
Neural Stem Cell Proliferation	inhibits	process	0.90
Neuronal Differentiation	inhibits	process	0.90
CRTH2	binds	receptor	0.90
Neuromyelitis Optica	biomarker_for	disease	0.90
proneural-mesenchymal transition	promotes	process	0.90
Glial Activation	regulates	process	0.90
Alzheimer'S Disease	involved_in	disease	0.90
ASTROCYTE	secreted_by	cell_type	0.90
Astrocyte Circadian Clock	associated_with	process	0.85
Amyloid Plaque Burden	modulates	phenotype	0.85
AD Progression	risk_factor_for	phenotype	0.85
Cognitive Impairment	correlates_with	phenotype	0.85
Neuroinflammation	biomarker_for	process	0.85
Microglia	modulates	cell_type	0.85
macrophage phenotype	modulates	phenotype	0.84
Astrocyte Activation	regulates	process	0.80
Microglial Activation	modulates	process	0.80
neural stem cells	inhibits	cell_type	0.80
Glial Phagocytosis	inhibits	process	0.75
Neurodegeneration	activates	disease	0.75
Autoimmune	activates	disease	0.75
Als	activates	disease	0.75
Phagocytosis	suppresses	process	0.75
ASTROCYTES	activates	gene	0.70
astrocytes	expressed_in	cell_type	0.70
stem cells	expressed_in	cell_type	0.70
neurons	expressed_in	cell_type	0.70
hippocampus	expressed_in	brain_region	0.70
Inflammation	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Aging	contributes_to	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Glioblastoma	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Ms	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Diabetes	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
ALS	biomarker_for	disease	0.65
Neuroinflammation	regulates	disease	0.65

Incoming (93)

Source	Relation	Type	Str
Astrocytes	expressed_in	cell_type	0.95
AQP4	regulates	protein	0.90
AQP4 Autoantibodies	upregulates	compound	0.90
Astrocyte	product_of	cell_type	0.90
hygromycin B	inhibits	drug	0.85
STAT3	regulates	protein	0.80
IL9	biomarker_for	gene	0.60
VEGFA	associated_with	gene	0.60
IL4	biomarker_for	gene	0.60
FGF2	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
NPTX1	associated_with	gene	0.60
CHIT1	associated_with	gene	0.60
MDH1	biomarker_for	gene	0.60
PDGFRB	associated_with	gene	0.60
SQSTM1	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
APOE	biomarker_for	gene	0.60
NEFL	biomarker_for	gene	0.60
AQP4	activates	gene	0.60
SPP1	regulates	gene	0.60
STAT3	activates	gene	0.60
GBM	activates	gene	0.60
EGF	therapeutic_target	gene	0.60
MMP1	activates	gene	0.60
HIF1A	activates	gene	0.60
MMP3	activates	gene	0.60
TNFAIP6	activates	gene	0.60
CD68	inhibits	gene	0.60
CLOCK	regulates	gene	0.60
TAU	associated_with	gene	0.60
APP	inhibits	gene	0.60
RAGE	inhibits	gene	0.60
ARG1	activates	gene	0.60
OVERVIEW	activates	gene	0.60
CXCL8	associated_with	gene	0.60
AIF1	biomarker_for	gene	0.60
C1QA	biomarker_for	gene	0.60
C1QB	biomarker_for	gene	0.60
C1QC	biomarker_for	gene	0.60
C1R	biomarker_for	gene	0.60
C1S	biomarker_for	gene	0.60
C3	biomarker_for	gene	0.60
NF-ΚB	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
APP/PS1	inhibits	gene	0.60
TAU PATHOLOGY	biomarker_for	gene	0.60
CYTOKINES	biomarker_for	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Integrated Biomarker Panel for Therapeutic Window Identifica	0.615	neurodegeneration	What are the precise temporal dynamics o

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the precise temporal dynamics of astrocyte ketone production decline du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.645

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHI3L1

Understanding Entity Pages

Summary

Wiki Pages (21)

YKL-40 (CHI3L1) - Biomarker

Alzheimer's Disease

Liquid Biopsy Diagnostics for Corticobasal Syndrome

Liquid Biopsy Diagnostics for Corticobasal Syndrome

er-stress-neurodegeneration

Biomarker Rankings

White Matter Degeneration

4R Tauopathy Differential Biomarkers

NPTX1 Protein

Section 179: Advanced Proteomics and Protein Biomarker Panels for CBS/PSP

Neuroinflammation in PD

VILIP-1 and YKL-40 - Alzheimer's Disease Biomarkers

TNFAIP6 — TNF Alpha Induced Protein 6 (TSG-6)

PSP Therapeutic Response Monitoring and Biomarkers

Multi-Analyte Biomarker Panels for Neurodegeneration

Oligodendrocyte Dysfunction in Neurodegeneration Pathway

Reactive Astrogliosis

YKL-40 (Chitinase-3-like protein 1)

Advanced Proteomics and Protein Biomarker Panels in CBS/PSP

Cerebrospinal Fluid (CSF) Biomarker Panels