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Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's disease

experiment Created: 2026-04-10 22:32:22 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-9549700c-9c56-4e13-90ea-8
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Related Entities
Chi3l1
Metadata
experiment_typeanimal_model
protocolHistological analysis of amyloid plaques and CD68 expression in APP/PS1 mice with and without Chi3l1
expected_outcomesChi3l1 deletion decreased plaque burden and increased periplaque CD68 expression
success_criteriaSignificant reduction in amyloid burden and increased phagocytic markers
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T15:32:22.434617
source_pmid33328329
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T22:32:22.487291'}
Linked Artifacts (81)
related🧫CHI3L1 variant association with AD progression in human pati100%
related🧫Chi3l1 deletion effects on baseline glial activation in mice100%
mentions📖CHI3L1 Gene80%
mentions📖CHI3L1 Protein (YKL-40)80%
related📖CHI3L1 Gene72%
related📖CHI3L1 Protein (YKL-40)72%
mentions📖APP-Overexpressing Neurons70%
mentions📖APP Arctic Mutation (APP Arctic)70%
mentions📖APP Dutch Mutation (APP Dutch)70%
mentions📖APP Flemish Mutation (APP Flemish)70%
mentions📖APP Swedish Mutation (APPswe)70%
mentions📖APP Gene70%
mentions📖app70%
mentions📖APP Gene Dosage Reduction Therapy for Down Syndrome70%
mentions📖APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chai70%
mentions📖APP Amyloid Pathway in Alzheimer's Disease70%
mentions📖APP-BACE1-Fe65 Complex70%
mentions📖APP Processing and Amyloid-Beta Production70%
mentions📖APP/PS1 Double Transgenic Mouse Model70%
mentions📖APP/PS1 Dual Transgenic Mouse Model70%
mentions📖APP Protein70%
mentions📖CD68 Gene70%
mentions📖CD68 Protein (Macrosialin)70%
related📖APP-Overexpressing Neurons63%
related📖APP Arctic Mutation (APP Arctic)63%
related📖APP Dutch Mutation (APP Dutch)63%
related📖APP Flemish Mutation (APP Flemish)63%
related📖APP Swedish Mutation (APPswe)63%
related📖APP Gene63%
related📖app63%
related📖APP Gene Dosage Reduction Therapy for Down Syndrome63%
related📖APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chai63%
related📖APP Amyloid Pathway in Alzheimer's Disease63%
related📖APP-BACE1-Fe65 Complex63%
related📖APP Processing and Amyloid-Beta Production63%
related📖APP/PS1 Double Transgenic Mouse Model63%
related📖APP/PS1 Dual Transgenic Mouse Model63%
related📖APP Protein63%
related📖CD68 Gene63%
related📖CD68 Protein (Macrosialin)63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
mentions📖Alzheimer's Disease Pathogenesis60%
mentions📖Microglia60%
mentions📖Microglia60%
related📖Alzheimer's Disease60%
related📖neuroinflammation55%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖Alzheimer's Disease Pathogenesis54%
related📖Microglia54%
related📖Microglia54%
mentions📖YKL-40 (CHI3L1) - Biomarker50%
mentions📖VILIP-1 and YKL-40 - Alzheimer's Disease Biomarkers50%
mentions📖YKL-40 (Chitinase 3-Like 1)50%
mentions📖Microglial Activation Biomarker Panel for Neurodegenerative 44%
mentions📖Advanced Proteomics and Protein Biomarker Panels in CBS/PSP44%