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Sex differences in CB1R-mediated cannabinoid analgesia in neuropathic pain

experiment Created: 2026-04-11 00:49:09 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-8ad644d2-5765-4323-8c44-5
🧫 Experiment Protocol Animal Model
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Related Entities
CNR1,CAMK2A,GAD2,SLC17A6
Metadata
experiment_typeanimal_model
protocolChronic constriction injury (CCI) model of sciatic nerve using 6-0 chromic gut sutures, viral tracing, immunohistochemistry, fluorescent in situ hybridization, RNAscope, conditional knockout, optogene
expected_outcomesFemale mice show superior analgesic responses to cannabinoids compared to males; CB1R deletion in mPFC-vlPAG pathway causes more severe pain in females; circuit-specific sex differences in synaptic pl
success_criteriaDemonstration of sex-specific differences in cannabinoid analgesia, identification of CB1R expression patterns, functional validation of mPFC-vlPAG circuit role
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T17:49:09.966378
source_pmid41380094
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-11T00:49:09.969702'}
🌍 Provenance Graph 1 nodes, 0 edges

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Linked Artifacts (198)
related🧫Electrophysiological analysis of mPFC-vlPAG synaptic transmi100%
mentions📖CAMK2A Gene80%
mentions📖CaMKII Protein (CaMK2A)80%
mentions📖CNR1 Gene80%
mentions📖CNR1 Protein80%
mentions📖Glutamate Decarboxylase 280%
mentions📖SLC17A6 Gene80%
mentions📖slc17a6 Protein80%
related📖CAMK2A Gene72%
related📖CaMKII Protein (CaMK2A)72%
related📖CNR1 Gene72%
related📖CNR1 Protein72%
related📖Glutamate Decarboxylase 272%
related📖SLC17A6 Gene72%
related📖slc17a6 Protein72%
mentions📖mechanisms60%
mentions📖Medial Prefrontal Cortex60%
mentions📖researchers60%
related📖mechanisms54%
related📖Medial Prefrontal Cortex54%
related📖researchers54%
mentions📖Endocannabinoid System Dysfunction Validation in Parkinson&#50%
mentions📖Cannabinoid CB1 Receptor Neurons50%
mentions📖Endocannabinoid System Dysfunction Hypothesis in Parkinson&#50%
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mentions📖Lateral Habenula Neurons50%
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mentions📖Medial Habenula Neurons50%
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mentions📖Mediodorsal Thalamic Nucleus Neurons50%
mentions📖Nucleus of the Brachium of the Inferior Colliculus50%
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mentions📖Nucleus of the Solitary Tract (NTS) Neurons50%
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mentions📖Preoptic Area Neurons50%
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mentions📖Pulvinar Neurons50%
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mentions📖Reticular Formation Neurons50%
mentions📖Parvicellular Reticular Formation Neurons50%
mentions📖Tectospinal Projection Neurons50%
mentions📖Thalamic Ventrobasal Neurons50%
mentions📖Tufted Cells50%
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mentions📖Nucleus Limitans Neurons50%
mentions📖Paraventricular Thalamic Nucleus (PVT) Neurons50%
mentions📖Reticularis Pontis Oralis Neurons50%
mentions📖Spinal Vestibular Nucleus (SpVN) Neurons50%
mentions📖Zona Incerta (ZI) Neurons50%
mentions📖Median Eminence Tanycytes50%
mentions📖Pedunculopontine Nucleus (PPN) Neurons - Expanded50%
related🧫CB1R expression mapping in mPFC-vlPAG circuit50%
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mentions📖Paraventricular Nucleus (PVN) CRH Neurons44%
mentions📖Pterygopalatine Ganglion (PPG) Neurons44%
mentions📖Neuroregeneration Therapies for Neurodegeneration44%
mentions📖Endocannabinoid System in Neurodegeneration44%
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mentions📖Pre-Bötzinger Complex Expanded v244%
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mentions📖Ventral Posterior Thalamic Nucleus (VPL/VPM) Neurons44%
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mentions📖Vesicular Glutamate Transporter (VGLUT) Neurons44%
mentions📖Vestibular Nuclei Complex (Expanded)44%
mentions📖Vestibular Nuclei Neurons44%
mentions📖Vestibular Nucleus Neurons44%
mentions📖Synaptic Vesicle Cycle44%

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