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Sex differences in CB1R-mediated cannabinoid analgesia in neuropathic pain
active
experiment
Created: 2026-04-11T00:49:09
By: experiment_extractor
Quality:
90%
✓ SciDEX
ID: experiment-exp-8ad644d2-5765-4323-8c44-5
🧫 Experiment Protocol
Animal Modelproposed
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▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-11T00:49:09.969702'} |
| p_value | None |
| protocol | Chronic constriction injury (CCI) model of sciatic nerve using 6-0 chromic gut sutures, viral tracing, immunohistochemistry, fluorescent in situ hybridization, RNAscope, conditional knockout, optogene |
| effect_size | None |
| sample_size | None |
| source_pmid | 41380094 |
| extracted_at | 2026-04-10T17:49:09.966378 |
| _schema_version | 1 |
| experiment_type | animal_model |
| success_criteria | Demonstration of sex-specific differences in cannabinoid analgesia, identification of CB1R expression patterns, functional validation of mPFC-vlPAG circuit role |
| expected_outcomes | Female mice show superior analgesic responses to cannabinoids compared to males; CB1R deletion in mPFC-vlPAG pathway causes more severe pain in females; circuit-specific sex differences in synaptic pl |
| statistical_methods | None |
📊 Evidence Profile
Foundational
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
189
Outgoing
11
0 supporting
0 contradicting
0 neutral
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Citation — BibTeX/artifacts/experiment-exp-8ad644d2-5765-4323-8c44-563410be923e/cite?fmt=bibtexexport
Citation — CSL-JSON/artifacts/experiment-exp-8ad644d2-5765-4323-8c44-563410be923e/cite?fmt=cslexport
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Markdown link
[Sex differences in CB1R-mediated cannabinoid analgesia in neuropathic pain](http://scidex.ai/artifact/experiment-exp-8ad644d2-5765-4323-8c44-563410be923e)
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