LAMP5+ Interneurons
<table class="infobox infobox-celltype">
<tr>
<th class="infobox-header" colspan="2">LAMP5+ Interneurons</th>
</tr>
<tr>
<td class="label">Allen Atlas ID</td>
<td><a href="https://portal.brain-map.org/atlases-and-data/rnaseq" target="_blank">CS202210140_3522</a></td>
</tr>
<tr>
<td class="label">Lineage</td>
<td>Neuron > GABAergic > Cortical interneuron > LAMP5+</td>
</tr>
<tr>
<td class="label">Markers</td>
<td>LAMP5, GAD1, GAD2, CALB2, CNR1</td>
</tr>
<tr>
<td class="label">Brain Regions</td>
<td>Cerebral cortex, Hippocampus</td>
</tr>
<tr>
<td class="label">Disease Vulnerability</td>
<td>[Alzheimer's Disease](/diseases/alzheimers-disease), [Epilepsy](/diseases/epilepsy)</td>
</tr>
</table>
LAMP5+ Interneurons
Introduction
Lamp5+ Interneurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
LAMP5+ Interneurons are a specialized cell type classified within the Neuron > GABAergic > Cortical interneuron > LAMP5+ lineage. These cells are primarily found in Cerebral cortex, Hippocampus and are characterized by expression of marker genes including LAMP5, GAD1, GAD2, CALB2. They are selectively vulnerable in Alzheimer's Disease, Epilepsy.
<!-- taxonomy-enrichment -->
<!-- multi-taxonomy-enrichment -->
Multi-Taxonomy Classification
Taxonomy Database Cross-References
...LAMP5+ Interneurons
<table class="infobox infobox-celltype">
<tr>
<th class="infobox-header" colspan="2">LAMP5+ Interneurons</th>
</tr>
<tr>
<td class="label">Allen Atlas ID</td>
<td><a href="https://portal.brain-map.org/atlases-and-data/rnaseq" target="_blank">CS202210140_3522</a></td>
</tr>
<tr>
<td class="label">Lineage</td>
<td>Neuron > GABAergic > Cortical interneuron > LAMP5+</td>
</tr>
<tr>
<td class="label">Markers</td>
<td>LAMP5, GAD1, GAD2, CALB2, CNR1</td>
</tr>
<tr>
<td class="label">Brain Regions</td>
<td>Cerebral cortex, Hippocampus</td>
</tr>
<tr>
<td class="label">Disease Vulnerability</td>
<td>[Alzheimer's Disease](/diseases/alzheimers-disease), [Epilepsy](/diseases/epilepsy)</td>
</tr>
</table>
LAMP5+ Interneurons
Introduction
Lamp5+ Interneurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
LAMP5+ Interneurons are a specialized cell type classified within the Neuron > GABAergic > Cortical interneuron > LAMP5+ lineage. These cells are primarily found in Cerebral cortex, Hippocampus and are characterized by expression of marker genes including LAMP5, GAD1, GAD2, CALB2. They are selectively vulnerable in Alzheimer's Disease, Epilepsy.
<!-- taxonomy-enrichment -->
<!-- multi-taxonomy-enrichment -->
Multi-Taxonomy Classification
Taxonomy Database Cross-References
| Taxonomy | ID | Name / Label |
|----------|----|---------------|
| Cell Ontology (CL) | [CL:4310084](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_4310084) | striatal LAMP5 CXCL14 GABAergic interneuron (Primate) |
Morphology & Electrophysiology
- Morphology: striatal LAMP5 CXCL14 GABAergic interneuron (Primate) (source: Cell Ontology)
- Morphology can be inferred from Cell Ontology classification
PanglaoDB Marker Cross-References
External Database Links
- [Cell Ontology (CL:4310084)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_4310084)
- [OBO Foundry (CL:4310084)](http://purl.obolibrary.org/obo/CL_4310084)
- [Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
- [CellxGene Census](https://cellxgene.cziscience.com/)
- [Human Cell Atlas](https://www.humancellatlas.org/)
- [PanglaoDB](https://panglaodb.se/)
Taxonomy & Classification
| Database | ID | Name | Confidence |
|----------|----|------|------------|
| Cell Ontology | [CL:4310084](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_4310084) | striatal LAMP5 CXCL14 GABAergic interneuron (Primate) | Medium |
PanglaoDB Marker Cross-References
External Database Links
- [Cell Ontology (CL:4310084)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_4310084)
- [OBO Foundry (CL:4310084)](http://purl.obolibrary.org/obo/CL_4310084)
- [Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
- [CellxGene Census](https://cellxgene.cziscience.com/)
- [PanglaoDB](https://panglaodb.se/)
Morphology and Markers
LAMP5+ Interneurons are identified by the expression of the following key marker genes:
- LAMP5
- GAD1
- GAD2
- CALB2
- CNR1
These markers are used for immunohistochemical identification and single-cell RNA sequencing classification, as catalogued in the [Allen Cell Type Atlas](https://portal.brain-map.org/atlases-and-data/rnaseq).
Normal Function
LAMP5+ Interneurons play essential roles in neural circuits and brain function. They are found in the following brain regions:
- Cerebral cortex
- Hippocampus
Their normal functions include maintaining neural circuit integrity, signal processing, and contributing to the homeostasis of their local microenvironment.
Vulnerability in Disease
LAMP5+ Interneurons show selective vulnerability in the following neurodegenerative conditions:
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- Epilepsy
The selective vulnerability of these cells is an active area of research, with factors including metabolic demands, calcium handling, exposure to toxic protein aggregates, and cell-autonomous gene expression programs contributing to their susceptibility.
Transcriptomic Profile
Single-cell and single-nucleus RNA sequencing studies have revealed the transcriptomic signature of LAMP5+ Interneurons. Key differentially expressed genes from the Allen Cell Type Atlas and related datasets include the marker genes listed above. These transcriptomic profiles help identify subtypes and disease-associated gene expression changes.
Key Publications
[LAMP5+ interneurons: a conserved cortical population](https://doi.org/10.1038/s41583-021-00460-8). Nat Rev Neurosci, 2021.
External Links
- Allen Cell Type Atlas: [https://portal.brain-map.org/atlases-and-data/rnaseq](https://portal.brain-map.org/atlases-and-data/rnaseq)
- Allen Human Brain Atlas: [https://human.brain-map.org/](https://human.brain-map.org/)
- [Cell Types Index](/cell-types)- [Diseases Index](/diseases)eases Index
- [Mechanisms Index](/mechanisms) --
Background
The study of Lamp5+ Interneurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.