🧫

Resveratrol protection against renal I/R injury in diabetic rats

experiment Created: 2026-04-11 00:45:03 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-8b61762b-2663-4111-9e71-d
🧫 Experiment Protocol Animal Model
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Related Entities
NFE2L2, HMOX1, TLR4, NFKB1
Metadata
experiment_typeanimal_model
protocolStreptozotocin induction of diabetes in rats, resveratrol pretreatment, renal ischemia/reperfusion induction, assessment of renal function, oxidative stress markers, inflammatory responses, apoptosis,
expected_outcomesRSV treatment expected to improve renal function, reduce oxidative stress and inflammation, decrease apoptosis, increase Nrf2/HO-1 expression, and decrease TLR4/NF-κB expression. ML385 treatment expec
success_criteriaSignificant improvement in renal function parameters, reduced oxidative stress markers, decreased inflammatory responses and apoptosis, increased Nrf2/HO-1 expression, decreased TLR4/NF-κB expression,
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T17:45:03.101026
source_pmid41958068
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-11T00:45:03.104229'}
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Linked Artifacts (35)
related🧫Resveratrol effects on HK-2 cells under hypoxia/reoxygenatio100%
mentions📖HMOX1 — Heme Oxygenase 180%
mentions📖HMOX1 Protein — Heme Oxygenase 180%
mentions📖NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 280%
mentions📖NFKB1 Gene80%
mentions📖NF-κB p105/p50 Protein80%
mentions📖TLR4 Gene80%
mentions📖TLR4 Protein80%
related📖HMOX1 — Heme Oxygenase 172%
related📖HMOX1 Protein — Heme Oxygenase 172%
related📖NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 272%
related📖NFKB1 Gene72%
related📖NF-κB p105/p50 Protein72%
related📖TLR4 Gene72%
related📖TLR4 Protein72%
mentions📖entities-tlr470%
mentions📖Toll-Like Receptor 4 (TLR4)70%
mentions📖TLR4 Antagonists for Neurodegeneration70%
related📖entities-tlr463%
related📖Toll-Like Receptor 4 (TLR4)63%
related📖TLR4 Antagonists for Neurodegeneration63%
mentions📖HO-1 Modulator Therapy50%
mentions📖p62/SQSTM1 (Sequestosome-1)50%
mentions📖dimethyl-fumarate-nrf2-ad-nct0685059750%
mentions📖Nrf2 Signaling in Neurodegeneration50%
mentions📖NRF2 Oxidative Stress Pathway50%
mentions📖Nrf2 Signaling in Parkinson's Disease50%
mentions📖Hypoxia Neuroprotection in Sporadic Parkinson's Disease44%
mentions📖NRF2 Therapeutics: Investment Landscape Analysis44%
mentions📖Arsenic Exposure and Alzheimer's Disease Mechanism44%
mentions📖NRF2-KEAP1 Oxidative Stress Response Pathway44%
mentions📖Epigenetic Therapies for Parkinson's Disease44%
mentions📖NRF2 Activator Therapy for Neurodegeneration44%
mentions📖TGR5 Agonist Therapy44%
mentions📖hpgv-parkinsons44%