🧫

E2F regulation of endocycles in trophoblast giant cells

experiment Created: 2026-04-06 12:29:34 By: experiment_extractor Quality: 85% ✓ SciDEX ID: experiment-exp-faa639b7-f54d-4974-bf5e-8
🧫 Experiment Protocol Animal Model
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Related Entities
E2F1, E2F2, E2F3, E2F7, E2F8
Metadata
experiment_typeanimal_model
protocollineage-specific cre-mediated gene ablation in trophoblast giant cells, ploidy measurement
expected_outcomescanonical E2F activator ablation increases ploidy, atypical E2F repressor ablation decreases ploidy
success_criteriameasurable changes in genome ploidy following E2F gene ablation
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-06T05:29:34.023403
source_pmid23064266
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:29:34.025754'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (78)
derives_from📄Canonical and atypical E2Fs regulate the mammalian endocycle100%
related🧫E2F regulation of endocycles in hepatocytes100%
mentions📖E2F1 Gene80%
mentions📖E2F8 Gene80%
related📖E2F1 Gene72%
related📖E2F8 Gene72%
mentions📖DNA Methylation Biomarkers in Neurodegeneration70%
mentions📖DNA Damage-Accumulating Neurons in Neurodegeneration70%
mentions📖DNA Damage and Repair in Neurons70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Methylation70%
mentions📖DNA Damage Repair Deficiency Validation Study in Parkinson&#70%
mentions📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 70%
mentions📖DNA Damage Repair Therapy - Biomarker Guided70%
mentions📖DNA Damage Repair Investment Landscape70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖dna-damage-repair70%
mentions📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas70%
mentions📖DNA Damage Response Impairment Pathway70%
mentions📖DNA Damage Response in 4R-Tauopathies70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Damage Response and Repair in Neurodegeneration70%
mentions📖DNA Damage Response in Neurons70%
mentions📖DNA Damage Response in Parkinson's Disease70%
mentions📖DNA Damage Response in Neurodegeneration70%
mentions📖DNA Methylation in Neurodegeneration70%
mentions📖DNA Repair Mechanisms in Neurodegeneration70%
mentions📖DNA Sensing Pathways in Neurodegeneration70%
mentions📖DNA Damage and Repair Dysfunction in PSP70%
mentions📖DNA Ligase III Protein70%
mentions📖DNA Ligase IV Protein70%
mentions📖DNA-PKcs (PRKDC) Protein70%
mentions📖DNA Damage Repair Therapy for Neurodegeneration70%
mentions📖DNA Repair Therapy for Neurodegeneration70%
mentions📖E2F Transcription Factor 270%
mentions📖E2F1 Protein70%
mentions📖E2F Transcription Factor 270%
mentions📖E2F3 Gene70%
mentions📖E2F7 Gene70%
related📖DNA Methylation Biomarkers in Neurodegeneration63%
related📖DNA Damage-Accumulating Neurons in Neurodegeneration63%
related📖DNA Damage and Repair in Neurons63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Methylation63%
related📖DNA Damage Repair Deficiency Validation Study in Parkinson&#63%
related📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 63%
related📖DNA Damage Repair Therapy - Biomarker Guided63%
related📖DNA Damage Repair Investment Landscape63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖dna-damage-repair63%
related📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas63%
related📖DNA Damage Response Impairment Pathway63%
related📖DNA Damage Response in 4R-Tauopathies63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Damage Response and Repair in Neurodegeneration63%
related📖DNA Damage Response in Neurons63%
related📖DNA Damage Response in Parkinson's Disease63%
related📖DNA Damage Response in Neurodegeneration63%
related📖DNA Methylation in Neurodegeneration63%
related📖DNA Repair Mechanisms in Neurodegeneration63%
related📖DNA Sensing Pathways in Neurodegeneration63%
related📖DNA Damage and Repair Dysfunction in PSP63%
related📖DNA Ligase III Protein63%
related📖DNA Ligase IV Protein63%
related📖DNA-PKcs (PRKDC) Protein63%
related📖DNA Damage Repair Therapy for Neurodegeneration63%
related📖DNA Repair Therapy for Neurodegeneration63%
related📖E2F Transcription Factor 263%
related📖E2F1 Protein63%
related📖E2F Transcription Factor 263%
related📖E2F3 Gene63%
related📖E2F7 Gene63%
mentions📖researchers60%
related📖researchers54%
mentions📖Cell Cycle Dysregulation in 4R-Tauopathies44%
mentions📖Cell Cycle Re-entry Pathway in Neurodegeneration44%