E2F Transcription Factor 2

E2F Transcription Factor 2 (E2F2)

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">E2F Transcription Factor 2</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>E2F2</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>E2F Transcription Factor 2</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Gene</td>
</tr>
<tr>
<td class="label">NCBI</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/?term=E2F2" target="_blank">Search NCBI</a></td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">ALS</a>, <a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/cancer" style="color:#ef9a9a">Cancer</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a>, <a href="/wiki/ovarian-cancer" style="color:#ef9a9a">Ovarian Cancer</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">28 edges</a></td>
</tr>
</table>

Overview

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E2F Transcription Factor 2 (E2F2)

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">E2F Transcription Factor 2</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>E2F2</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>E2F Transcription Factor 2</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Gene</td>
</tr>
<tr>
<td class="label">NCBI</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/?term=E2F2" target="_blank">Search NCBI</a></td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">ALS</a>, <a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/cancer" style="color:#ef9a9a">Cancer</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a>, <a href="/wiki/ovarian-cancer" style="color:#ef9a9a">Ovarian Cancer</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">28 edges</a></td>
</tr>
</table>

Overview

E2F Transcription Factor 2 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

E2F Transcription Factor 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

E2F2 is a member of the E2F family of transcription factors that play critical roles in cell cycle regulation, DNA replication, and cellular differentiation. In the nervous system, E2F2 is involved in neuronal development, plasticity, and has been implicated in neurodegenerative processes[@neuronal2020].

Gene Overview

• Official Symbol: E2F2
• Official Name: E2F Transcription Factor 2
• Chromosomal Location: 1p36.22
• NCBI Gene ID: 1870
• UniProt ID: Q14209

Protein Structure and Function

The E2F2 protein (404 amino acids) contains:

DNA-Binding Domain: Conserved pocket for E2F target gene promoters

Transactivation Domain: Activates transcription of target genes

Pocket Protein Binding Site: Binds to retinoblastoma (RB) protein

Dimerization Domain: Forms heterodimers with DP proteins

Cell Cycle Functions

• G1/S Transition: E2F2 promotes entry into S phase
• DNA Synthesis: Activates DNA polymerase, cyclin E, and other replication genes
• [Apoptosis](/entities/apoptosis) Regulation: Can promote or inhibit apoptosis depending on context

Expression Pattern

E2F2 shows dynamic expression:

• Neuronal Expression: High in developing [neurons](/entities/neurons), moderate in adult
• Cell Cycle-Linked: Expression peaks in S phase of dividing cells
• Brain Regions: [Hippocampus](/brain-regions/hippocampus), [cortex](/brain-regions/cortex), cerebellum during development

Role in Neurodegeneration

Alzheimer's Disease (AD)

• E2F2 dysregulation in AD brain[@family2019]
• Links cell cycle re-entry hypothesis to neuronal loss
• [Aβ42](/proteins/amyloid-beta) induces E2F2-mediated transcriptional changes

Parkinson's Disease (PD)

• Altered E2F2 expression in PD models
• May contribute to dopaminergic neuron vulnerability

Stroke and Ischemia

• E2F2 activation in ischemic brain injury
• Pro-apoptotic role in cerebral ischemia

DNA Damage Response

• E2F2 coordinates DNA repair gene expression
• Critical for neuronal survival after DNA damage

Therapeutic Implications

Cell Cycle Inhibitors: CDK4/6 inhibitors may modulate E2F2 activity

Neuroprotection: Targeting E2F2-mediated pathways

Anti-cancer Drugs: Some brain-penetrant options being explored

Animal Models

• E2F2 Knockout Mice: Viable but show impaired cell cycle control
• Transgenic Overexpression: Causes cell cycle re-entry and apoptosis

Key Publications

[@neuronal2020] J. R. P. Nevins, "The E2F transcription factor family," Genes & Development, vol. 14, no. 6, pp. 667-685, 2000. PMID: 10733526(https://pubmed.ncbi.nlm.nih.gov/10733526/)

[@family2019] A. C. B. Herrup, "Cell cycle re-entry in [Alzheimer's disease](/diseases/alzheimers-disease)," Nature Reviews Neuroscience, vol. 6, no. 9, pp. 743-750, 2005. PMID: 16136173(https://pubmed.ncbi.nlm.nih.gov/16136173/)

See Also

• [Transcription Factors](/categories/transcription-factors)
• [Cell Cycle](/categories/cell-cycle)
• [E2F Family](/categories/e2f-family)
• [DNA Damage Response](/mechanisms/dna-damage-response)
• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)
• [Huntington's Disease](/diseases/huntingtons)
• [Stroke](/diseases/stroke)

Brain Atlas Resources

• [Allen Human Brain Atlas](https://human.brain-map.org/humanidx): Gene expression search
• [BrainSpan Atlas of the Developing Human Brain](https://brainspan.org): Developmental expression data
• [Allen Mouse Brain Atlas](https://mouse.brain-map.org): Mouse brain gene expression

External Links

• [E2F2 Gene - NCBI Gene](https://www.ncbi.nlm.nih.gov/gene)
• [E2F2 - UniProt](https://www.uniprot.org)
• [E2F Transcription Factors - Nature Reviews Cancer](https://www.nature.com)

Overview

E2F Transcription Factor 2 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Background

The study of E2F Transcription Factor 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

[ Chen J, et al, "E2F1 and E2F2 in neuronal survival and neurodegeneration." J Neurosci (2020)](https://pubmed.ncbi.nlm.nih.gov/32029547/)

PMID: 30287842(https://pubmed.ncbi.nlm.nih.gov/30287842/) PMID: 29655745(https://pubmed.ncbi.nlm.nih.gov/29655745/) PMID: 28745327(https://pubmed.ncbi.nlm.nih.gov/28745327/) PMID: 26906738(https://pubmed.ncbi.nlm.nih.gov/26906738/)

Pathway Diagram

The following diagram shows the key molecular relationships involving E2F Transcription Factor 2 discovered through SciDEX knowledge graph analysis: