Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Longitudinal Mechanism Study

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Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Longitudinal Mechanism Study

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experiment Created: 2026-04-02T10:01:41 By: crosslink-v2 Quality: 67% ✓ SciDEX ID: experiment-exp-wiki-experiments-migraine

🧫 Experiment Protocol Clinicalproposed

SUMMARY

# Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Longitudinal Mechanism Study ## Background and Rationale This longitudinal clinical study investigates the mechanistic relationship between migraine-associated cortical hyperexcitability and Alzheimer's disease (AD) risk through cortical spreading depression (CSD) pathways. Growing epidemiological evidence suggests migraineurs have altered AD risk profiles, but underlying neurobiological mechanisms remain unclear. CSD, the patho

METHODOLOGY NOTES

Phase 1 (Months 1-6): Recruit 400 participants: 200 migraine patients (≥2 attacks/month, aura present in ≥50%) and 200 age-matched controls. Conduct comprehensive baseline assessments including medical history, Montreal Cognitive Assessment (MoCA), and establish informed consent. Phase 2 (Months 7-12): Perform baseline multimodal neuroimaging using 3T MRI with diffusion tensor imaging, arterial spin labeling, and glymphatic function assessment via gadolinium-based contrast studies. Collect CSF via lumbar puncture and blood samples for amyloid-β42/40 ratio, phosphorylated tau-181, neurofilament light chain, and inflammatory markers (IL-1β, TNF-α, CGRP). Phase 3 (Years 1-10): Conduct annual follow-up visits including cognitive testing battery (neuropsychological assessment, episodic memory tasks), repeat neuroimaging every 2 years, and biomarker collection annually. Implement continuous ambulatory EEG monitoring (72-hour periods quarterly) using high-density electrode arrays to detect CS

▸Metadatasource: {'type': 'manual', 'source_name': 'wiki'

source	{'type': 'manual', 'source_name': 'wiki', 'extracted_by': 'backfill_v1', 'extraction_date': '2026-04-16T01:00:16.899136Z'}
summary	# Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Longitudinal Mechanism Study ## Background and Rationale This longitudinal clinical study investigates the mechanistic relationship
entities	{'genes': ['CSD'], 'diseases': ["Alzheimer's Disease"]}
model_system	human
_schema_version	1
experiment_type	clinical
primary_outcome	Validate Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Longitudinal Mechanism Study
methodology_notes	Phase 1 (Months 1-6): Recruit 400 participants: 200 migraine patients (≥2 attacks/month, aura present in ≥50%) and 200 age-matched controls. Conduct comprehensive baseline assessments including medica
replication_status	single_study
extraction_metadata	{'backfill_at': '2026-04-16T01:00:16.899141', 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'extraction_confidence': 0.4}

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Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Longitudinal Mechanism Study

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