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BMS-986446 Phase 2 Trial for Early Alzheimer's Disease

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-clinical-trials-bms-986446-early-ad
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clinical-trials-bms-986446-early-ad-nct06268886
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entity_typeclinical
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Linked Artifacts (609)
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see_also📖DNA Damage Response in Alzheimer's Disease80%
see_also📖DNA Damage Response in Alzheimer's Disease80%
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see_also📖Familial Alzheimer's Disease Genetics80%
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see_also📖Neurofibrillary Tangle Propagation in Alzheimer's Disea80%
see_also📖Adult Hippocampal Neurogenesis: Impaired in Alzheimer's80%
see_also📖Neuroimmune Genes in Alzheimer's Disease — TREM2, CD33,80%
see_also📖Neuroinflammation in Alzheimer's Disease80%
see_also📖Neuroinflammation in Alzheimer's Disease80%
see_also📖Neuroinflammation Hypothesis in Alzheimer's Disease80%
see_also📖Neuronal Death Pathways in Alzheimer's Disease80%
see_also📖Neurovascular Dysfunction in Alzheimer's Disease: Integ80%
see_also📖NLRP3 Inflammasome Pathway in Alzheimer's Disease80%
see_also📖NRTI Immunomodulation in Alzheimer's Disease: Molecular80%
see_also📖PKM2 Metabolic Dysregulation in Alzheimer's Disease80%
see_also📖RNA Metabolism Dysregulation in Alzheimer's Disease80%
see_also📖RNA Metabolism in Alzheimer's Disease80%
see_also📖Sex-Specific Mechanisms in Alzheimer's Disease80%
see_also📖SIRT1 Signaling Pathway in Alzheimer's Disease80%
see_also📖Sleep and Circadian Dysfunction in Alzheimer's Disease80%
see_also📖Sleep Disruption in Alzheimer's Disease80%
see_also📖Sporadic Alzheimer's Disease Pathway80%
see_also📖SYK Kinase in Microglial Activation and Alzheimer's Dis80%
see_also📖SYK Kinase in Microglial Activation and Alzheimer's Dis80%
see_also📖Synaptic Dysfunction in Alzheimer's Disease80%
see_also📖Synaptic Loss in Alzheimer's Disease80%
see_also📖Synaptic Loss in Alzheimer's Disease Pathway80%
see_also📖Synaptic Spine Degradation Pathway in Alzheimer's Disea80%
see_also📖Tanshinone IIA-Pretreated MSC Therapy for Alzheimer's D80%
see_also📖Tau Kinase-Phosphatase Balance in Alzheimer's Disease80%
see_also📖Tau Kinase Signaling Cascade in Alzheimer's Disease80%
see_also📖Tau Pathology Alters Oligodendrocyte Gene Methylation in [Al80%
see_also📖Tau Pathology in Alzheimer's Disease80%
see_also📖Tau Phosphorylation Pathway in Alzheimer's Disease80%
see_also📖TREM2 Microglia Pathway in Alzheimer's Disease80%
see_also📖TREM2→Microglial Dysfunction→Alzheimer's Disease Causal80%
see_also📖Type 3 Diabetes Hypothesis of Alzheimer's Disease80%
see_also📖TYROBP/DAP12 Microglia Signaling Pathway in Alzheimer's80%
see_also📖Ubiquitin-Proteasome System in Alzheimer's Disease Path80%
see_also📖Ubiquitin-Proteasome System Dysfunction in Alzheimer's 80%
see_also📖Vascular Contributions to Alzheimer's Disease80%
see_also📖Vascular Dementia Mechanisms — Overlap with Alzheimer's80%
see_also📖Vascular Risk Factors in Alzheimer's Disease80%
see_also📖Alzheimer's Disease Neuroimaging Initiative (ADNI)80%
see_also📖Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD)80%
see_also📖Alzheimer's Disease Brain Banks and Tissue Repositories80%
see_also📖AI-Powered Diagnostics for Alzheimer's Disease80%
see_also📖BCI for Alzheimer's Disease80%
see_also📖Memory Prosthetic BCI for Alzheimer's Disease80%
see_also📖Positron Emission Tomography in Alzheimer's Disease80%
see_also📖Failed Alzheimer's Disease Clinical Trials Analysis80%
see_also📖RNA-Based Therapeutics for Alzheimer's Disease80%
see_also📖ALSENLITE: Senolytics for Alzheimer's Disease Trial80%
see_also📖Alzheimer's Disease Treatment80%
see_also📖Amyloid Immunotherapy Vaccines for Alzheimer's Disease80%
see_also📖Anti-Amyloid Immunotherapy Comparison Matrix for Alzheimer&#80%
see_also📖Anti-Tau Immunotherapies for Alzheimer's Disease80%
see_also📖Bumetanide — Alzheimer's Disease80%
see_also📖CAR-A Therapy — Chimeric Antigen Receptor Astrocytes for Alz80%
see_also📖CAR-A Therapy - Chimeric Antigen Receptor Astrocytes for Alz80%
see_also📖CAR-A (Chimeric Antigen Receptor) Astrocyte Therapy for Alzh80%
see_also📖CAR-T Cell Therapy for Alzheimer's Disease80%
see_also📖Disease-Modifying Therapies for Alzheimer's Disease80%
see_also📖Ferulic Acid Carbamate Derivatives for Alzheimer's Dise80%
see_also📖Kamuvudine-9: NRTI for Alzheimer's Disease Neuroinflamm80%
see_also📖Memantine - NMDA Antagonist for Alzheimer's Disease80%
see_also📖Nanomedicine for Alzheimer's Disease80%
see_also📖Nanomedicine Approaches to Alzheimer's Disease80%
see_also📖Siponimod for Alzheimer's Disease80%
see_also📖Sodium Oligomannate (GV-971) for Alzheimer's Disease80%
see_also📖Tau Immunotherapy for Alzheimer's Disease80%
see_also📖TREM2 Agonist Therapies for Alzheimer's Disease80%
related🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia72%
related🧪GFAP-Positive Reactive Astrocyte Subtype Delineation72%
related🧪Complement C1QA Spatial Gradient in Cortical Layers72%
related🧪Excitatory Neuron Vulnerability via SLC17A7 Downregulation72%
related🧪APOE Isoform Expression Across Glial Subtypes72%
related🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro72%
related🧪Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli72%
related🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK72%
related🧫ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De70%
related🧫ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De70%
see_also📖Parkin Protein60%
related🧫s:** - Test whether HCN1 knockout specifically in EC layer I60%
related🧫Proposed experiment from debate on Synaptic pruning by micro60%
related🧫Brain Connectivity-Targeted tACS Trial in Early AD60%
related🧫CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs 60%
related🧫4R-Tau Targeting Therapies for PSP and CBS60%
related🧫AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi60%
related🧫AD Combination Therapy Trial: Anti-Aβ + Anti-Tau60%
related🧫Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti60%
related🧫Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?60%
related🧫Animal Model Comparison for Neurodegenerative Disease Therap60%
related🧫Anti-Tau Immunotherapy Dosing Optimization60%
related🧫ApoE4 Function in Alzheimer's Disease60%
related🧫Experiment: Autoimmune Hypothesis Testing in AD60%
related🧫Autophagy Enhancement Drug Screening for Neurodegeneration60%
related🧫Biomarker-Guided Sequential Therapy Selection in Alzheimer&#60%
related🧫Blood-Based Biomarker Panel for Early AD Detection60%
related🧫tACS Connectivity Trial in Early Alzheimer's60%
related🧫Brain Connectivity-Targeted tACS Trial in Early AD60%
related🧫Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated 60%
related🧫Cognitive Reserve Mechanisms in Alzheimer's Disease — M60%
related🧫Cholinergic System Dysfunction in DLB — Mechanisms and Thera60%
related🧫Down Syndrome Alzheimer's Disease: Mechanisms and Thera60%
related🧫Epigenetic Regulation Dysfunction in Alzheimer's and Pa60%
related🧫FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation60%
related🧫Gap Junction Dysfunction Validation in Parkinson's Dise60%
related🧫Lifestyle Intervention Mechanisms in Alzheimer's Diseas60%
related🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise60%
related🧫Microbiome-Gut-Brain Axis in Alzheimer's Disease — mech60%
related🧫Microglial Aging and Immune Memory in Neurodegeneration — Tr60%
related🧫Migraine Cortical Hyperexcitability and Alzheimer's Dis60%
related🧫Mixed Pathology Effects on Parkinson's Disease Progress60%
related🧫Neural Stem Cell Therapy for Alzheimer's Disease60%
related🧫Normal Aging to Alzheimer's Disease Transition Trigger 60%
related🧫CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs 60%
related🧫Prion Strain Diversity and Selective Vulnerability60%
related🧫SCFA-Mediated Neuroinflammation in Alzheimer's Disease60%
related🧫Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer&#60%
related🧫Sex Differences in Alzheimer's Disease — mechanisms and60%
related🧫Sleep Disruption and Alzheimer's Disease — mechanism an60%
related🧫Traumatic Brain Injury and Alzheimer's Disease Relation60%
related🧫Experiment Validation: In vitro ThT Assay60%
related🧫Tau ASO Therapy60%
related🧫Microglial TREM2 Agonist In Vivo Efficacy60%
related🧫TREM2 Function in Alzheimer's Disease — From Risk Varia60%
related🧫Vascular Contribution to Alzheimer's Disease — Beyond A60%
related🧫Vascular Contributions to Alzheimer Disease and Mixed Pathol60%
related🧫Viral Infections and Alzheimer's Disease — causal mecha60%
related🧫s:** - Test whether HCN1 knockout specifically in EC layer I54%
related🧫Proposed experiment from debate on Synaptic pruning by micro54%
related🧫Brain Connectivity-Targeted tACS Trial in Early AD54%
related🧫CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs 54%
related🧫4R-Tau Targeting Therapies for PSP and CBS54%
related🧫AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi54%
related🧫AD Combination Therapy Trial: Anti-Aβ + Anti-Tau54%
related🧫Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti54%
related🧫Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?54%
related🧫Animal Model Comparison for Neurodegenerative Disease Therap54%
related🧫Anti-Tau Immunotherapy Dosing Optimization54%
related🧫ApoE4 Function in Alzheimer's Disease54%
related🧫Experiment: Autoimmune Hypothesis Testing in AD54%
related🧫Autophagy Enhancement Drug Screening for Neurodegeneration54%
related🧫Biomarker-Guided Sequential Therapy Selection in Alzheimer&#54%
related🧫Blood-Based Biomarker Panel for Early AD Detection54%
related🧫tACS Connectivity Trial in Early Alzheimer's54%
related🧫Brain Connectivity-Targeted tACS Trial in Early AD54%
related🧫Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated 54%
related🧫Cognitive Reserve Mechanisms in Alzheimer's Disease — M54%
related🧫Cholinergic System Dysfunction in DLB — Mechanisms and Thera54%
related🧫Down Syndrome Alzheimer's Disease: Mechanisms and Thera54%
related🧫Epigenetic Regulation Dysfunction in Alzheimer's and Pa54%
related🧫FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation54%
related🧫Gap Junction Dysfunction Validation in Parkinson's Dise54%
related🧫Lifestyle Intervention Mechanisms in Alzheimer's Diseas54%
related🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise54%
related🧫Microbiome-Gut-Brain Axis in Alzheimer's Disease — mech54%
related🧫Microglial Aging and Immune Memory in Neurodegeneration — Tr54%
related🧫Migraine Cortical Hyperexcitability and Alzheimer's Dis54%
related🧫Mixed Pathology Effects on Parkinson's Disease Progress54%
related🧫Neural Stem Cell Therapy for Alzheimer's Disease54%
related🧫Normal Aging to Alzheimer's Disease Transition Trigger 54%
related🧫CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs 54%
related🧫Prion Strain Diversity and Selective Vulnerability54%
related🧫SCFA-Mediated Neuroinflammation in Alzheimer's Disease54%
related🧫Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer&#54%
related🧫Sex Differences in Alzheimer's Disease — mechanisms and54%
related🧫Sleep Disruption and Alzheimer's Disease — mechanism an54%
related🧫Traumatic Brain Injury and Alzheimer's Disease Relation54%
related🧫Experiment Validation: In vitro ThT Assay54%
related🧫Tau ASO Therapy54%
related🧫Microglial TREM2 Agonist In Vivo Efficacy54%
related🧫TREM2 Function in Alzheimer's Disease — From Risk Varia54%
related🧫Vascular Contribution to Alzheimer's Disease — Beyond A54%
related🧫Vascular Contributions to Alzheimer Disease and Mixed Pathol54%
related🧫Viral Infections and Alzheimer's Disease — causal mecha54%
mentions🧪HSP90-Tau Disaggregation Complex Enhancement50%
mentions🧪VCP-Mediated Autophagy Enhancement50%
mentions🧪LRP1-Dependent Tau Uptake Disruption50%
mentions🧪Extracellular Vesicle Biogenesis Modulation50%
mentions🧪Prefrontal sensory gating circuit restoration via PV interne50%
mentions🧪Synaptic Vesicle Tau Capture Inhibition50%
mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%
mentions🧪TREM2-mediated microglial tau clearance enhancement50%
mentions🧪Gamma entrainment therapy to restore hippocampal-cortical sy50%
mentions🧪Trans-Synaptic Adhesion Molecule Modulation50%
mentions🧪Stress Granule Phase Separation Modulators50%
mentions🧪Phase-Separated Organelle Targeting50%
related🔬What are the mechanisms underlying microglia-astrocyte cross50%
related🔬What are the mechanisms underlying rna binding protein dysre50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%
related🔬The disease-associated microglia (DAM) phenotype involves TR50%
related🔬What are the mechanisms underlying tdp-43 phase separation t50%
related🔬What are the mechanisms underlying microglia-astrocyte cross50%
related🔬What are the mechanisms underlying digital biomarkers and ai50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
related🔬What are the mechanisms underlying rna binding protein dysre50%
related🔬What are the mechanisms underlying synaptic pruning by micro50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬The disease-associated microglia (DAM) phenotype involves TR50%
related🔬Is disrupted sleep a cause or consequence of neurodegenerati50%
related🔬Is disrupted sleep a cause or consequence of neurodegenerati50%
related🔬Extracellular vesicle biomarkers for early AD detection50%
related🔬Comprehensive analysis of immune cell subtypes in neurodegen50%
related🔬What cell types are most vulnerable in Alzheimers Disease ba50%
related🔬What cell types are most vulnerable in Alzheimer's Dise50%
related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%
related🔬What are the most promising therapeutic strategies for targe50%
related🔬How to break the GBA-alpha-synuclein bidirectional loop for 50%
related🔬Can gut-brain axis modulation prevent or slow Alzheimer'50%
related🔬TDP-43 undergoes liquid-liquid phase separation that becomes50%
related🔬Astrocytes adopt A1 (neurotoxic) and A2 (neuroprotective) ph50%
related🔬Synaptic pruning by microglia in early AD50%
related🧪Noradrenergic-Tau Propagation Blockade50%
see_also📖TREM2-SYK Signaling Cascade50%
see_also📖GSK-3β Protein50%
see_also📖Transferrin Protein50%
see_also📖ran45%
see_also📖TREM2 Microglial Priming Inhibitor for Pre-Symptomatic Neuro45%
see_also📖Glial-Neuron Crosstalk in Parkinson's Disease45%
see_also📖LRP1-ApoE Signaling Cascade45%
see_also📖TREM2-APOE Axis in Neurodegeneration45%
see_also📖Hepsin Protein45%
see_also📖Ubiquitin Protein45%
see_also📖Neuroinflammation Modulation Therapy: GFAP and sTREM2-Target45%
see_also📖Retinoid Pathway Modulator Therapy for Neurodegenerative Dis45%
see_also📖Tissue Engineered Nigrostriatal Pathway for Parkinson's45%
mentions🔬Extracellular vesicle biomarkers for early AD detection40%
mentions🔬What cell types are most vulnerable in Alzheimer's Dise40%
mentions🔬What are the most promising therapeutic strategies for targe40%
mentions🔬Can gut-brain axis modulation prevent or slow Alzheimer'40%
mentions🔬What cell types are most vulnerable in Alzheimers Disease ba40%
mentions🔬How to break the GBA-alpha-synuclein bidirectional loop for 40%
mentions🔬The disease-associated microglia (DAM) phenotype involves TR40%
mentions🔬What are the mechanisms underlying what are the mechanisms b40%
mentions🔬What are the mechanisms underlying what are the mechanisms b40%
mentions🔬The disease-associated microglia (DAM) phenotype involves TR40%
mentions🔬Is disrupted sleep a cause or consequence of neurodegenerati40%
mentions🔬Is disrupted sleep a cause or consequence of neurodegenerati40%
mentions🔬Comprehensive analysis of immune cell subtypes in neurodegen40%
mentions🔬Astrocytes adopt A1 (neurotoxic) and A2 (neuroprotective) ph40%
mentions🔬What are the mechanisms underlying digital biomarkers and ai40%
mentions🔬What are the mechanisms underlying synaptic pruning by micro40%
mentions🔬Synaptic pruning by microglia in early AD40%
mentions🔬What are the mechanisms underlying tdp-43 phase separation t40%
mentions🔬TDP-43 undergoes liquid-liquid phase separation that becomes40%
related🧪HSP90-Tau Disaggregation Complex Enhancement40%
related🧪VCP-Mediated Autophagy Enhancement40%
related🧪LRP1-Dependent Tau Uptake Disruption40%
related🧪Extracellular Vesicle Biogenesis Modulation40%
related🧪Prefrontal sensory gating circuit restoration via PV interne40%
related🧪Synaptic Vesicle Tau Capture Inhibition40%
related🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna40%
related🧪Stress Granule Phase Separation Modulators40%
related🧪TREM2-mediated microglial tau clearance enhancement40%
related🧪Gamma entrainment therapy to restore hippocampal-cortical sy40%
related🧪Phase-Separated Organelle Targeting40%
related🧪Trans-Synaptic Adhesion Molecule Modulation40%

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