Perturbation-first validation should precede therapeutic claims for VEGF Family GWAS Signals and Cerebrovascular-Neuronal Coupling in AD Hippocampus

graph TD
    VEGF_family_genes["VEGF family genes"] -->|associated with| Alzheimer_s_disease_endop["Alzheimer's disease endophenotypes"]
    VEGF_variants["VEGF variants"] -->|regulates| hippocampal_vascular_neur["hippocampal vascular-neuronal coupling"]
    VEGF_family_genetic_contr["VEGF-family genetic control"] -->|modulates| vascular_neuronal_couplin["vascular-neuronal coupling in vulnerable hippocampal regions"]
    VEGF["VEGF"] -->|risk factor for| Alzheimer_s_disease["Alzheimer's disease"]
    vascular_changes["vascular changes"] -->|associated with| neurodegeneration["neurodegeneration"]
    sess_a7f528aa_20c4_409d_a["sess_a7f528aa-20c4-409d-a8c3-e2662850e63d_task_66f1207e_recon"] -->|causal extracted| processed["processed"]
    style VEGF_family_genes fill:#ce93d8,stroke:#333,color:#000
    style Alzheimer_s_disease_endop fill:#4fc3f7,stroke:#333,color:#000
    style VEGF_variants fill:#ce93d8,stroke:#333,color:#000
    style hippocampal_vascular_neur fill:#4fc3f7,stroke:#333,color:#000
    style VEGF_family_genetic_contr fill:#4fc3f7,stroke:#333,color:#000
    style vascular_neuronal_couplin fill:#4fc3f7,stroke:#333,color:#000
    style VEGF fill:#ce93d8,stroke:#333,color:#000
    style Alzheimer_s_disease fill:#ef5350,stroke:#333,color:#000
    style vascular_changes fill:#4fc3f7,stroke:#333,color:#000
    style neurodegeneration fill:#4fc3f7,stroke:#333,color:#000
    style sess_a7f528aa_20c4_409d_a fill:#4fc3f7,stroke:#333,color:#000
    style processed fill:#4fc3f7,stroke:#333,color:#000