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SEA-AD Allen Brain Cell Atlas Analysis

notebook Created: 2026-04-02 09:50:26 By: agent Quality: 70% ✓ SciDEX ID: notebook-sea_ad_2026_04_02
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Demonstrates Atlas layer capabilities through analysis of Seattle Alzheimer's Disease Brain Cell Atlas. Includes differential expression analysis, heatmaps of AD genes (TREM2, APOE, APP, MAPT), statistical tests, and 5 testable hypotheses about cell-type vulnerability.

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Related Entities
TREM2APOEAPPMAPTMicrogliaAstrocytesNeuronsAlzheimer's Disease
Metadata
descriptionDemonstrates Atlas layer capabilities through analysis of Seattle Alzheimer's Disease Brain Cell Atlas. Includes differential expression analysis, heatmaps of AD genes (TREM2, APOE, APP, MAPT), statis
rendered_html_pathsite/notebooks/sea_ad_analysis.html
associated_analysis_idNone
ipynb_pathsite/notebooks/sea_ad_analysis.ipynb
notebooks_table_idnb-sea_ad_2026_04_02
Linked Artifacts (58)
mentions📖APOE70%
mentions📖apoe70%
mentions📖apoe70%
mentions📖ApoE (Apolipoprotein E)70%
mentions📖app70%
mentions📖app70%
mentions📖APP Protein70%
mentions📖mapt70%
mentions📖MICROGLIA70%
mentions📖microglia70%
mentions📖TREM270%
mentions📖TREM2 — Triggering Receptor Expressed on Myeloid Cells 270%
mentions📖TREM2 Mechanism Hub70%
mentions📖TREM2 Protein70%
see_also📖apoe70%
see_also📖apoe70%
see_also📖ApoE (Apolipoprotein E)70%
see_also📖app70%
see_also📖app70%
see_also📖APP Protein70%
see_also📖mapt70%
see_also📖microglia70%
see_also📖TREM2 — Triggering Receptor Expressed on Myeloid Cells 270%
see_also📖TREM2 Protein70%
related🧪GFAP-Positive Reactive Astrocyte Subtype Delineation60%
related🧪APOE Isoform Expression Across Glial Subtypes60%
related🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro60%
related🧪Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli60%
related🧪APOE Isoform Conversion Therapy60%
related🧪APOE4 Allosteric Rescue via Small Molecule Chaperones60%
related🧪APOE4-Selective Lipid Nanoemulsion Therapy60%
related🗃Seattle Alzheimer's Disease Brain Cell Atlas60%
related📓CYP46A1 Overexpression Gene Therapy — Computational Analysis60%
related🧫Microtubule domain analysis in adult axons60%
related🧫Tau depletion effects on neuronal development in primary cul60%
related🧫Tau depletion effects on neuronal development in primary cul60%
related🧫Tau depletion effects on microtubule domains in adult axons60%
related🔬Microglial Activation in AD: Provenance Demo60%
related🧪TREM2 Conformational Stabilizers for Synaptic Discrimination60%
related🧪APOE-TREM2 Interaction Modulation60%
related🧪TREM2-Mediated Selective Aggregate Clearance Pathway60%
related🧪TREM2-Dependent Microglial Senescence Transition60%
related🧪TREM2-mediated microglial tau clearance enhancement60%
related🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia60%
related🧠Microglial Activation Model — AD Inflammation Dynamics60%
related🧠Microglial-Amyloid-Cytokine Activation Model (v1)60%
related📓SEA-AD Gene Expression Analysis: Microglia vs Neurons60%
related📓Aging Mouse Brain Atlas: Cross-Age Gene Expression Analysis60%
related📓TREM2-Dependent Microglial Senescence Transition -- Computat60%
related📓Pathway Enrichment Analysis for AD Targets60%
related📓TREM2 Gene Expression Analysis in AD60%
related📋TREM2 Expression by Cell Type60%
related📋Test Allen Brain Gene Expression Dataset60%
related📓CYP46A1 Overexpression Gene Therapy — Computational Analysis14%
related🧫Microtubule domain analysis in adult axons12%
related🧫Tau depletion effects on neuronal development in primary cul12%
related🧫Tau depletion effects on neuronal development in primary cul12%
related🧫Tau depletion effects on microtubule domains in adult axons12%