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Patient selection**: Which patients are most likely to benefit from LRRK2-targeted therapies?
active
open question
Created: 2026-04-25T20:29:28
By: backfill_open_questions
Quality:
50%
✓ SciDEX
ID: open_question-43be22e1-dd15-4162-ad42-f8
Open Question
open
Wiki: entities-lrrk2
Patient selection**: Which patients are most likely to benefit from LRRK2-targeted therapies?
Importance Elo
1500
Field Rank
Rank #61 in entities
Tractability
0.50
Potential Impact
0.50
Evidence Summary
Extracted from wiki page entities-lrrk2
Secondary Market
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Share Holder Leaderboard
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Evidence Bearing On This Question
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develop PD
candidate answer · experiment · 82%
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy
partial answer for · experiment · 45%
AAV Serotype Comparison for LRRK2 Knockdown in PD
partial answer for · experiment · 45%
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown
partial answer for · experiment · 45%
AAV-LRRK2 IND-Enabling Study Design
bears on question · experiment · 40%
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
bears on question · experiment · 40%
Pairwise Tournament History
No pairwise judgments recorded yet.
Derived Hypotheses And Proposals
No derived artifacts linked yet.
Related Entities
▸Metadata
| status | open |
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-26T03:29:28.800933'} |
| field_tag | entities |
| source_id | entities-lrrk2 |
| sub_field | lrrk2 |
| source_kind | wiki |
| question_hash | d4585514880e83ec6019b1d70421932a775fd9d8947edefe2792117219dc118a |
| question_text | Patient selection**: Which patients are most likely to benefit from LRRK2-targeted therapies? |
| importance_elo | 1500 |
| _schema_version | 1 |
| evidence_summary | Extracted from wiki page entities-lrrk2 |
| evidence_xref_at | 2026-04-27T14:33:39.533143+00:00 |
| tractability_score | 0.5 |
| potential_impact_score | 0.5 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
7
0 supporting
0 contradicting
0 neutral
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