gene 2,407 words KG: ent-gene-9f063e98 2026-03-26
kind:genesection:genesstate:published
Contents

LRRK2 (Leucine-Rich Repeat Kinase 2) — Comprehensive Gene Review

🧬 Gene Info
Gene SymbolLRRK2
Full NameLRRK2 (Leucine-Rich Repeat Kinase 2) — Comprehensive Review
Chromosome12q12
Protein TypeProtein
Amino Acids2527 aa
PathwaysMAPK
UniProt IDSearch UniProt
NCBI Gene IDSearch NCBI
GeneCardsLRRK2
Human Protein AtlasLRRK2
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN, levodopa, Cigarette Smoking, MLi-2, PF-06447475, Environmental Toxicants
InteractionsATG16L1, RB1CC1, GABARAP, ERN1, STAT3, IFNG
KG Connections2480 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Glycine-Rich Domain Competitive Inhibition
Score: 0.43
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived

Related Experiments (23)

AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-9f063e98 data_in benchmark_ot_ad_answer_key:LRRK2
benchmark_ot_ad_answer_key:LRRK2 data_in ent-gene-9f063e98