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Structure and function of nicotinamide mononucleotide adenylyltransferase.
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ID: paper-15078171
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Structure and function of nicotinamide mononucleotide adenylyltransferase.
["Magni G", "Amici A", "Emanuelli M", "Orsomando G", "Raffaelli N", "Ruggieri S"]
Abstract
The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT), a member of the nucleotidyltransferase alpha/beta phosphodiesterase superfamily, catalyzes the reaction NMN + ATP = NAD + PPi, representing the final step in the biosynthesis of NAD, a molecule playing a fundamental role as a cofactor in cellular redox reactions. NAD also serves as the substrate for reactions involved in important regulatory roles, such as protein covalent modifications, like ADP-ribosylation reactions, as well ...
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