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Integrating NHANES and network toxicology to assess the impact of organophosphate flame retardants on cardiovascular disease.
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ID: paper-41804832
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Integrating NHANES and network toxicology to assess the impact of organophosphate flame retardants on cardiovascular disease.
Dai K, Huang Y, Cai H, Zhong G, Xie Z, Wu S, Huang D
Abstract
Cardiovascular disease (CVD) pathogenesis involves multifactorial determinants, including environmental pollutants. This study integrated National Health and Nutrition Examination Survey (NHANES) data and network toxicology approaches to investigate the association and underlying molecular mechanisms between organophosphate flame retardant (OPFR) metabolites and CVD risk. Weighted multivariable logistic regression and restricted cubic splines (RCS) were employed to analyze OPFR metabolites-CVD a...
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