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The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
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ID: paper-25658443
📄 Paper Details
The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
["Abdiche Y", "Yeung Y", "Chaparro-Riggers J", "Barman I", "Strop P", "Chin S", "Pham A", "Bolton G", "McDonough D", "Lindquist K"]
Abstract
The neonatal Fc receptor (FcRn) is expressed by cells of epithelial, endothelial and myeloid lineages and performs multiple roles in adaptive immunity. Characterizing the FcRn/IgG interaction is fundamental to designing therapeutic antibodies because IgGs with moderately increased binding affinities for FcRn exhibit superior serum half-lives and efficacy. It has been hypothesized that 2 FcRn molecules bind an IgG homodimer with disparate affinities, yet their affinity constants are inconsistent ...
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📊 Evidence Profile
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+0%
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