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Functional polymorphisms in rhesus macaque FCGRT and β2-m.
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ID: paper-28785825
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Functional polymorphisms in rhesus macaque FCGRT and β2-m.
Shubin Z, Tagaya Y, Poonia B
Abstract
Rhesus macaque is an important animal model for studies testing interventions like antibody therapeutics; as such knowledge of inter-individual variations in function of genes affecting antibody recycling is important for optimal experimental design. Neonatal Fc receptor (FcRn), a heterodimer composed of FCGRT and β2-m chains, plays critical role in extending catabolic half-life of IgG. We studied genomic polymorphisms in rhesus macaque FcRn and asked if they are functional by assessing correlat...
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