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Acoustic biosensors for ultrasound imaging of enzyme activity.
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ID: paper-32661379
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Acoustic biosensors for ultrasound imaging of enzyme activity.
["Lakshmanan A", "Jin Z", "Nety S", "Sawyer D", "Lee-Gosselin A", "Malounda D", "Swift M", "Maresca D", "Shapiro M"]
Abstract
Visualizing biomolecular and cellular processes inside intact living organisms is a major goal of chemical biology. However, existing molecular biosensors, based primarily on fluorescent emission, have limited utility in this context due to the scattering of light by tissue. In contrast, ultrasound can easily image deep tissue with high spatiotemporal resolution, but lacks the biosensors needed to connect its contrast to the activity of specific biomolecules such as enzymes. To overcome this lim...
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