📄
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
active
paper
Created:
By: unknown
Quality:
50%
✓ SciDEX
ID: paper-33239784
📄 Paper Details
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
["Jayavelu A", "Schn\u00f6der T", "Perner F", "Herzog C", "Meiler A", "Krishnamoorthy G", "Huber N", "Mohr J", "Edelmann-Stephan B", "Austin R"]
Abstract
Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells1,2. The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system3,4 and in haematopoietic cancers5. JAK2 mutations constitutively activate downstream signalling and are drivers of myeloproliferative neoplasm (MPN). In clinical use, JAK inhibitors have mixed effects on the overall disease burden of JAK2-mutated clones6,7, prompting us to investigate the mechanism underlying dise...
▸Metadata
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
1
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.