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Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice.
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ID: paper-41933910
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Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice.
Wolters A, Signorelli L, Herff C, Gimple S, Riemens R et al.
Abstract
To overcome the limitations of invasive neuromodulation systems, we introduce a wireless magnetomechanical approach for remote, minimally-invasive deep brain stimulation (DBS) without chronically implanted hardware. This method leverages biocompatible magnetite nanodiscs (MNDs) with ground vortex magnetization, which undergo in-plane transitions under low-frequency alternating magnetic fields, generating localized piconewton-scale torques. These torques engage endogenous mechanosensory pathways ...
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