Liver-specific knockout of CD73 exacerbated alcohol-associated steatohepatitis by regulating adenosine signalling and hepatic clock gene BMAL1.

Alcohol-associated liver disease (ALD) is a leading cause of morbidity and premature mortality worldwide, characterized by hepatic steatosis and inflammatory cell infiltration. CD73, predominantly expressed in hepatocytes, has been implicated in the regulation of hepatocyte metabolism and liver homeostasis. However, whether and how hepatocyte CD73 contributes to ALD pathogenesis remains poorly understood and warrants systematic investigation. In this study, we observed that CD73 expression was s...