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Fig. 1: SPP1 upregulation at onset of microglia–synapse phagocytosis. a , Representative...
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Created: 2026-04-15T23:28:06
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Fig. 1Figure 1
SPP1 upregulation at onset of microglia–synapse phagocytosis. a , Representative 3D reconstructed images showing Homer1 engulfment within CD68 + lysosomes of P2Y12 + microglia in 6-month App WT (WT) versus App NL-F CA1 hippocampal SLM. Scale bar represents 5 µm. b , Quantification of Homer1 engulfment in 6-month WT and App NL-F P2Y12 + microglia. One datapoint represents average of 1 mouse from n = 4 animals per genotype examined over two independent experiments. P values from two-tailed unpaired Student’s t -test with Welch’s correction. c , Representative confocal images of C1q protein expression in 6-month WT versus App NL-F mice. Insert represents C1qa mRNA within Tmem119 + microglia. Scale bar represents 20 µm. Data are representative of two mice per genotype examined over at least five independent experiments. d , Quantification of C1q puncta in 6-month WT and App NL-F CA1 hippocampus. One datapoint represents one ROI per mouse from n = 9 WT mice and n
▸Metadata
| doi | |
| pmcid | PMC9991912 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig1_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-15T23:28:06.196081'} |
| caption | SPP1 upregulation at onset of microglia–synapse phagocytosis. a , Representative 3D reconstructed images showing Homer1 engulfment within CD68 + lysosomes of P2Y12 + microglia in 6-month App WT (W |
| paper_id | 36747024 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig1_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 1 |
| figure_number | 1 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
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Incoming
0
Outgoing
1
0 supporting
0 contradicting
0 neutral
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