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Extended Data Fig. 5: SPP1 deficiency prevents synapse loss upon oAβ challenge. (a ) Scheme illustrati...
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Created: 2026-04-15T23:28:06
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ID: paper-fig-36747024-10
Extended Data Fig. 5Figure 10
SPP1 deficiency prevents synapse loss upon oAβ challenge. (a ) Scheme illustrating tail vein (TV) injection of 100ng S26C oAβ versus PBS in WT versus Spp1 KO/KO mice, 72 h before tissue collection and analysis. (b) Representative super-resolution images of Homer1 and Bassoon puncta colocalization in 3 mo WT and Spp1 KO/KO SR injected with oAβ versus PBS control, at 72 h post-TV injection. Scale bar represents 5 µm. ( c ) Quantification of Homer1/Bassoon colocalization density, represented as S26C oAβ-injected mice normalized to PBS injected mice. 1 datapoint represents the average of 1 animal (3–5 ROIs per animal, 40 cells per ROI) with a total of n = 4 mice per genotype. Data are from one experiment. P Values from multiple unpaired t -tests, Bonferroni’s multiple comparison test. Data are shown as Mean ± SEM.
Source data
▸Metadata
| doi | |
| pmcid | PMC9991912 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig10_ESM.jpg', 'type': 'external', 'tracked_at': '2026-04-15T23:28:06.336410'} |
| caption | SPP1 deficiency prevents synapse loss upon oAβ challenge. (a ) Scheme illustrating tail vein (TV) injection of 100ng S26C oAβ versus PBS in WT versus Spp1 KO/KO mice, 72 h before tissue collection a |
| paper_id | 36747024 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig10_ESM.jpg |
| image_path | |
| description | |
| figure_label | Extended Data Fig. 5 |
| figure_number | 10 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
1
0 supporting
0 contradicting
0 neutral
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