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Fig. 3: GSEA of custom mitochondrial and immune pathways in osteocytes, hBMSCs, and brai...
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Created: 2026-04-22T15:50:11
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Fig. 3Figure 3
GSEA of custom mitochondrial and immune pathways in osteocytes, hBMSCs, and brain under spaceflight. (“GSEA-Cust Infl_MITO”): this is a GSEA custom pathway analysis according to [ 94 ]. Normalized enrichment scores (NES) for mitochondrial- and immune-related modules (rows) are plotted as lollipops for osteocytes (2, 4, 6 days; mouse), hBMSCs (14 days; human), and brain (84 days; mouse) comparing spaceflight to ground controls. A positive NES indicates pathway activation (red), and a negative NES indicates inhibition (blue). Circle size is inversely proportional to the false discovery rate (FDR); only results with FDR < 0.3 are shown. Pathways were defined in collaboration with D. Wallace [ 94 ], and include modules for antigen presentation, innate immunity, PANoptosis (apoptosis, necroptosis, inflammasome), oxidative phosphorylation (OXPHOS) complexes I–V and mitochondrial ribosome, mtDna/dsrna immune sensing and vesicle release, integrated stress response (ISR), unfolded protein respo
▸Metadata
| doi | 10.1186/s12967-025-07505-z |
| pmcid | PMC12829014 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12829014/bin/12967_2025_7505_Fig3_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-22T22:50:11.397969'} |
| caption | GSEA of custom mitochondrial and immune pathways in osteocytes, hBMSCs, and brain under spaceflight. (“GSEA-Cust Infl_MITO”): this is a GSEA custom pathway analysis according to [ 94 ]. Normalized enr |
| paper_id | 6512908d-5fae-41e7-acab-de26b310cea2 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12829014/bin/12967_2025_7505_Fig3_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 3 |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
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